21-hydroxylase deficiency secondary prevention
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mehrian Jafarizade, M.D [2]
Overview
Continued monitoring of hormone balance and careful readjustment of glucocorticoid dose is helpful in controlling fertility and preventing adrenal crisis in patient with 21-hydroxylase deficiency.
Secondary Prevention
Preventing hyperandrogenism and optimizing fertility
Continued monitoring of hormone balance and careful adjustment of glucocorticoid dose is helpful in controlling infertility. In general, women with 21-hydroxylase deficiency have a lower fertility rate.[1]
Preventing adrenal crisis
To prevent adrenal crisis, all patients taking glucocorticoids replacement should take bolus dose of glucocorticoids during severe illness, surgery and severe exhaustion.
References
- ↑ Mnif MF, Kamoun M, Kacem FH, Mnif F, Charfi N, Naceur BB, Rekik N, Abid M (2013). “Reproductive outcomes of female patients with congenital adrenal hyperplasia due to 21-hydroxylase defi ciency”. Indian J Endocrinol Metab. 17 (5): 790–3. doi:10.4103/2230-8210.117196. PMC 3784860. PMID 24083158.
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