APOM
Apolipoprotein M is a protein that in humans is encoded by the APOM gene.[1][2][3]
The protein encoded by this gene is an apolipoprotein and member of the lipocalin protein family. It is found associated with high density lipoproteins and to a lesser extent with low density lipoproteins and triglyceride-rich lipoproteins. The encoded protein is secreted through the plasma membrane but remains membrane-bound, where it is involved in lipid transport. Two transcript variants encoding two different isoforms have been found for this gene, but only one of them has been fully characterized.[3] The average molecular weight is 21253 Da, and the monoisotopic molecular weight is 21239 Da.
References
- ↑ Xu N, Dahlback B (Dec 1999). “A novel human apolipoprotein (apoM)”. J Biol Chem. 274 (44): 31286–90. doi:10.1074/jbc.274.44.31286. PMID 10531326.
- ↑ Duan J, Dahlback B, Villoutreix BO (Jun 2001). “Proposed lipocalin fold for apolipoprotein M based on bioinformatics and site-directed mutagenesis”. FEBS Lett. 499 (1–2): 127–32. doi:10.1016/S0014-5793(01)02544-3. PMID 11418126.
- ↑ 3.0 3.1 “Entrez Gene: APOM apolipoprotein M”.
Further reading
- Albertella MR, Jones H, Thomson W, et al. (1997). “Localization of eight additional genes in the human major histocompatibility complex, including the gene encoding the casein kinase II beta subunit (CSNK2B)”. Genomics. 36 (2): 240–51. doi:10.1006/geno.1996.0459. PMID 8812450.
- Xu N, Zhang XY, Dong X, et al. (2002). “Effects of platelet-activating factor, tumor necrosis factor, and interleukin-1alpha on the expression of apolipoprotein M in HepG2 cells”. Biochem. Biophys. Res. Commun. 292 (4): 944–50. doi:10.1006/bbrc.2002.6755. PMID 11944906.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Zhang XY, Dong X, Zheng L, et al. (2003). “Specific tissue expression and cellular localization of human apolipoprotein M as determined by in situ hybridization”. Acta Histochem. 105 (1): 67–72. doi:10.1078/0065-1281-00687. PMID 12666989.
- Mungall AJ, Palmer SA, Sims SK, et al. (2003). “The DNA sequence and analysis of human chromosome 6”. Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
- Richter S, Shih DQ, Pearson ER, et al. (2004). “Regulation of apolipoprotein M gene expression by MODY3 gene hepatocyte nuclear factor-1alpha: haploinsufficiency is associated with reduced serum apolipoprotein M levels”. Diabetes. 52 (12): 2989–95. doi:10.2337/diabetes.52.12.2989. PMID 14633861.
- Xie T, Rowen L, Aguado B, et al. (2004). “Analysis of the Gene-Dense Major Histocompatibility Complex Class III Region and Its Comparison to Mouse”. Genome Res. 13 (12): 2621–36. doi:10.1101/gr.1736803. PMC 403804. PMID 14656967.
- Zhang XY, Jiao GQ, Hurtig M, et al. (2005). “Expression pattern of apolipoprotein M during mouse and human embryogenesis”. Acta Histochem. 106 (2): 123–8. doi:10.1016/j.acthis.2003.11.004. PMID 15147633.
- Kabbara A, Payet N, Cottel D, et al. (2004). “Exclusion of CYP46 and APOM as candidate genes for Alzheimer’s disease in a French population”. Neurosci. Lett. 363 (2): 139–43. doi:10.1016/j.neulet.2004.03.066. PMID 15172102.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). “The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Xu N, Nilsson-Ehle P, Ahrén B (2005). “Correlation of apolipoprotein M with leptin and cholesterol in normal and obese subjects”. J. Nutr. Biochem. 15 (10): 579–82. doi:10.1016/j.jnutbio.2004.03.001. PMID 15542348.
- Luo G, Hurtig M, Zhang X, et al. (2005). “Leptin inhibits apolipoprotein M transcription and secretion in human hepatoma cell line, HepG2 cells”. Biochim. Biophys. Acta. 1734 (2): 198–202. doi:10.1016/j.bbalip.2005.02.005. PMID 15904876.
- Liu T, Qian WJ, Gritsenko MA, et al. (2006). “Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry”. J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
- Niu N, Zhu X, Liu Y, et al. (2007). “Single nucleotide polymorphisms in the proximal promoter region of apolipoprotein M gene (apoM) confer the susceptibility to development of type 2 diabetes in Han Chinese”. Diabetes Metab. Res. Rev. 23 (1): 21–5. doi:10.1002/dmrr.641. PMID 16572495.
- Christoffersen C, Nielsen LB, Axler O, et al. (2006). “Isolation and characterization of human apolipoprotein M-containing lipoproteins”. J. Lipid Res. 47 (8): 1833–43. doi:10.1194/jlr.M600055-JLR200. PMID 16682745.
- Karlsson H, Lindqvist H, Tagesson C, Lindahl M (2006). “Characterization of apolipoprotein M isoforms in low-density lipoprotein”. J. Proteome Res. 5 (10): 2685–90. doi:10.1021/pr060180x. PMID 17022639.
- Xu X, Ye Q, Xu N, et al. (2007). “Effects of ischemia-reperfusion injury on apolipoprotein M expression in the liver”. Transplant. Proc. 38 (9): 2769–73. doi:10.1016/j.transproceed.2006.08.133. PMID 17112825.
- Ahnström J, Faber K, Axler O, Dahlbäck B (2007). “Hydrophobic ligand binding properties of the human lipocalin apolipoprotein M”. J. Lipid Res. 48 (8): 1754–62. doi:10.1194/jlr.M700103-JLR200. PMID 17525477.
External links
- Applied Research on apoM
- Human APOM genome location and APOM gene details page in the UCSC Genome Browser.
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