Achlorhydria laboratory findings

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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• Blood Tests: Blood tests such as iron indices, [calcium]], prothrombin time, vitamin B 12, vitamin D, serum folate, and thiamine levels should be checked to exclude deficiencies and anemia.
• Measurement of basal acid secretion and gastric pH: These are the most important and basic study to prove the presence of the condition of achlorhydria. A pH of greater than 3.5 is commonly used to identify achlorhydria, and more than 50% of them whose initial stomach pH is 4.0 or higher.
• Gastrin levels: Serum gastrin level in patients with achlorhydria is very high. A serum gastrin levels higher than 500-1000 pg/mL may suggest a diagnosis of achlorhydria.
• Antiparietal cell antibody testing: Achlorhydria shows a strong association with autoimmune conditions. Many patients with achlorhydria can be detected antiparietal cell antibody.

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