Acute chest syndrome natural history, complications and prognosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Overall mortality in patients with ACS is 1.8%, however in adults the rate is 4.3%.
There is no difference between patients with Hb SS and Hb SC.
Unfortunately, there have been no presenting signs, symptoms or laboratory data that is predictive of who will die.
A trend to increased mortality has been observed in patients with a lower presenting hemoglobin, multilobar involvement on CXR, and bacteremia.
Patients who die, tend to do so very rapidly and unexpectedly.