M2 AML

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

M2 is a subtype of AML (Acute Myeloid Leukemia).

This subtype is characterized by a translocation of a part of chromosome 8 to chromosome 21, written as t(8;21). On both sides of the chromosome, now containing pieces from two chromosomes, the DNA codes for different proteins. These two proteins are now being created as one single large protein, with a different effect in the body as the two proteins originally coded by the two different chromosomes. The two different proteins that are fused together are:

• RUNX1
• ETO

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