Acute myeloblastic leukemia with maturation

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

M2 is a subtype of AML (Acute Myeloid Leukemia).

It is also known as “Acute Myeloblastic Leukemia with Maturation”.^[1]

Cause

This subtype is characterized by a translocation of a part of chromosome 8 to chromosome 21, written as t(8;21).^[2] On both sides of the chromosome, now containing pieces from two chromosomes, the DNA codes for different proteins. These two proteins are now being created as one single large protein, with a different effect in the body as the two proteins originally coded by the two different chromosomes.

The two different proteins that are fused together are:

RUNX1
ETO

References

↑ “Acute Myeloid Leukemia – Signs and Symptoms”.
↑ Taj AS, Ross FM, Vickers M; et al. (1995). “t(8;21) myelodysplasia, an early presentation of M2 AML”. Br. J. Haematol. 89 (4): 890–2. PMID 7772527.

External links

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[urlAcute_Myeloid_Leukemia_-_Signs_and_Symptoms-1] “Acute Myeloid Leukemia – Signs and Symptoms”.

[pmid7772527-2] Taj AS, Ross FM, Vickers M; et al. (1995). “t(8;21) myelodysplasia, an early presentation of M2 AML”. Br. J. Haematol. 89 (4): 890–2. PMID 7772527.

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[2]