Adrenoleukodystrophy epidemiology and demographics

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

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Adrenoleukodystrophy is the most common peroxisomal disorder, with an estimated incidence of 1 in 17,000 births (male and female) and 1 in 21,000 males in the United States. The prevalence of X-linked adrenoleukodystrophy is approximately 1 in 20,000 individuals. This condition occurs with a similar frequency in all populations. The lifetime prevalence of adrenal insufficiency in ALD is ~80%.

• Adrenoleukodystrophy is the most common peroxisomal disorder, with an estimated incidence of 1 in 17,000 births (male and female) and 1 in 21,000 males in the United States. ^[1]

• The prevalence of X-linked adrenoleukodystrophy is approximately 1 in 20,000 individuals. This condition occurs with a similar frequency in all populations.

• The lifetime prevalence of adrenal insufficiency in ALD is ~80%. ^[2]

• Childhood cerebral type commonly occurs in 3-10 years of age.^[3]
• AMN type has a median age of 28 years.^[3]
• Addison disease type occurs in 0 to (greater or equal to) 10 years of age.^[3]
• Cerebellar type can occur in childhood or adolescence.

There is no racial predilection to adrenoleukodystrophy.

• Men are more commonly affected by adrenoleukodystrophy than women. However, women can be a carrier of the disease.

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