Alpha 1-antitrypsin deficiency CT
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mazia Fatima, MBBS [2]
Overview
On high-resolution CT (HRCT) scan of the chest alpha 1-antitrypsin deficiency presents as hypoattenuated areas resulting from a lack of lung tissue. As tissue is lost, pulmonary vessels appear smaller, fewer in number, and spread farther apart. Mild forms of alpha1-antitrypsin disease can be missed on HRCT scanning. However, when the disease is moderate, there is panlobular and characteristic lower zone predominance. Severe forms vary from severe centrilobular emphysema. Normal lung structures have been replaced by abnormal airspaces. CT of abdomen may show hepatomegaly or changes associated with cirrhosis or hepatocellular carcinoma.
CT
On High-resolution CT (HRCT) scan of the chest:[1]
- Hypoattenuated areas present due to loss lung tissue. Pulmonary vessels are smaller, fewer and spread farther apart.
- In cases of moderate severity, there is the panlobular and characteristic lower zone predominance.
- Severe disease is indistinguishable from severe centrilobular emphysema. Normal lung structures have been replaced by abnormal airspaces.
- CT of abdomen can present as hepatomegaly and associated with cirrhosis or hepatocellular carcinoma.
References
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