Amphotericin B lipid complex overdosage

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmed Zaghw, M.D. [2]

Amphotericin B desoxycholate overdose has been reported to result in cardio-respiratory arrest. Fifteen patients have been reported to have received one or more doses of ABELCET® between 7-13 mg/kg. None of these patients had a serious acute reaction to ABELCET®.

If an overdose is suspected:

1. Discontinue therapy
2. Monitor the patient’s clinical status
3. Administer supportive therapy as required. ABELCET® is not hemodialyzable.^[1]

Adapted from the FDA Package Insert.