Anal fissure laboratory findings

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Amandeep Singh M.D.[2]

Primary anal fissure is usually diagnosed and confirmed by clinical history and physical examination. Laboratory findings are needed to rule out the causes of secondary anal fissures e.g. Crohn’s disease, tuberculosis, sarcoidosis, and HIV which include lymphocytosis, Enzyme linked immunosorbent assay (ELISA).

• Primary anal fissure is usually diagnosed and confirmed by clinical history and physical examination. Usually, laboratory findings are needed to rule out the causes of secondary anal fissures e.g. Crohn’s disease, tuberculosis, sarcoidosis and HIV.
• Laboratory findings consistent with the diagnosis of a secondary anal fissure include:^[1]
  • Leukocytosis– lymphocytosis
  • ESR
  • HIV tests
  • TB tests (IGRA, or biopsy)

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