Analgesic nephropathy history and symptoms

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Shakiba Hassanzadeh, MD[2]

Common findings in patients with analgesic nephropathy include: headache, upper gastrointestinal disease (such as peptic ulcer), anemia, urinary tract infections, pyuria and hypertension.

History, symptoms and and clinical findings in patients with analgesic nephropathy includes:^[1][2]

• Headache
• Upper gastrointestinal disease (such as peptic ulcer)
• Anemia (60%)
• Psychiatric disorder  
• Urinary tract infections (15-60%) 
• Sterile pyuria (95%)  
• Hypertension (15-70%)
• Tubular epithelial celluria
• Microscopic hematuria (35%)
• Significant proteinuria (greater than 0.3 gr daily) (40%)
• Transitional cell tumours of the urothelium (in abuse of analgesics containing phenacetin)
• Varying degrees of renal failure (over 85%)
• Clinical gout (5%)
• Acidosis  
• Passage of papillae  
• Flank or abdominal pain    

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