Ankylosing spondylitis historical perspective

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Manpreet Kaur, MD [2]

Overview

Galen was the first to distinguish the difference between ankylosing spondylitis and rheumatoid arthritis.Realdo Colombo has first described ankylosing spondylitis.Bernard Connor was first to describe ankylosing spondylitis pathologic changes.

In 2nd century, Galen was the first to distinguish the difference between ankylosing spondylitis and rheumatoid arthritis.^[1]
A 5000-year-old Egyptian mummy skeletal remains shows skeletal evidence of the disease ankylosing spondylitis.^[2]
Ankylosing spondylitis was first described by Realdo Colombo,a anatomist and surgeon, in in 1559.^[3]
Ankylosing spondylitis pathologic changes was first described by Bernard Connor,in 1691.

Monoclonal antibodies was developed to treat ankylosing spondylitis was an important landmark events in the treatment strategies.^[4]

↑ Dieppe P (January 1988). “Did Galen describe rheumatoid arthritis?”. Ann. Rheum. Dis. 47 (1): 84–5. PMC 1003452. PMID 3278697.
↑ Saleem SN, Hawass Z (December 2014). “Ankylosing spondylitis or diffuse idiopathic skeletal hyperostosis in royal Egyptian mummies of 18th -20th Dynasties? CT and archaeology studies”. Arthritis Rheumatol. 66 (12): 3311–6. doi:10.1002/art.38864. PMID 25329920.
↑ Benoist M (April 1995). “Pierre Marie. Pioneer investigator in ankylosing spondylitis”. Spine. 20 (7): 849–52. PMID 7701402.
↑ Sieper J (2009). “Developments in the scientific and clinical understanding of the spondyloarthritides”. Arthritis Res. Ther. 11 (1): 208. doi:10.1186/ar2562. PMC 2688219. PMID 19232062.