Anti-citrullinated protein antibody

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Anti-citrullinated protein antibodies (ACPA) or anti-cyclic citrullinated protein antibodies (anti-CCP) are autoantibodies (antibodies against human tissues) frequently detected in rheumatoid arthritis. The main epitope for these antibodies is filaggrin, and there is cross-reactivity between ACPA and anti-keratin and anti-perinuclear factor.^[1] In a comparative study, various detection kits had a sensitivity between 69.6% and 77.5% and a specificity between 87.8% and 96.4%.^[2] Given that ACPA is more specific than rheumatoid factor, it is used to distinguish various causes of arthritis.^[3]

References

↑ Schellekens GA, de Jong BA, van den Hoogen FH, van de Putte LB, van Venrooij WJ (1998). “Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies”. J. Clin. Invest. 101 (1): 273–81. doi:10.1172/JCI1316. PMID 9421490. Unknown parameter |month= ignored (help) PMC 508564
↑ Coenen D, Verschueren P, Westhovens R, Bossuyt X (2007). “Technical and diagnostic performance of 6 assays for the measurement of citrullinated protein/peptide antibodies in the diagnosis of rheumatoid arthritis”. Clin. Chem. 53 (3): 498–504. doi:10.1373/clinchem.2006.078063. PMID 17259232. Unknown parameter |month= ignored (help)
↑ Avouac J, Gossec L, Dougados M (2006). “Diagnostic and predictive value of anti-cyclic citrullinated protein antibodies in rheumatoid arthritis: a systematic literature review”. Ann. Rheum. Dis. 65 (7): 845–51. doi:10.1136/ard.2006.051391. PMID 16606649. Unknown parameter |month= ignored (help)

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[1] Schellekens GA, de Jong BA, van den Hoogen FH, van de Putte LB, van Venrooij WJ (1998). “Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies”. J. Clin. Invest. 101 (1): 273–81. doi:10.1172/JCI1316. PMID 9421490. Unknown parameter |month= ignored (help) PMC 508564

[2] Coenen D, Verschueren P, Westhovens R, Bossuyt X (2007). “Technical and diagnostic performance of 6 assays for the measurement of citrullinated protein/peptide antibodies in the diagnosis of rheumatoid arthritis”. Clin. Chem. 53 (3): 498–504. doi:10.1373/clinchem.2006.078063. PMID 17259232. Unknown parameter |month= ignored (help)

[3] Avouac J, Gossec L, Dougados M (2006). “Diagnostic and predictive value of anti-cyclic citrullinated protein antibodies in rheumatoid arthritis: a systematic literature review”. Ann. Rheum. Dis. 65 (7): 845–51. doi:10.1136/ard.2006.051391. PMID 16606649. Unknown parameter |month= ignored (help)

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