Aspergillosis other diagnostic studies

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]; Yazan Daaboul, M.D.; Serge Korjian M.D.

Skin biopsy may be helpful in the diagnosis of cutaneous aspergillosis.^[1][2]

• Skin biopsy is helpful in the diagnosis of cutaneous aspergillosis.
• Histopathologic examination with hematoxylin and eosin will variably demonstrate Aspergillus hyphae.^[2]
• The Gomori methenamine silver stain, however, clearly detects hyphae, since the hyphal cell wall stains black, while the background tissue stains green.
• Aspergillus hyphae should have acute-angle branching and frequent septations on histopathological examination.

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  This image depicts histopathologic changes indicating aspergillosis of the lung of a caged parrot caused by A. fumigatus. From Public Health Image Library (PHIL). ^[3]
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  This image depicts histopathologic changes indicating aspergillosis of the lung of a caged parrot caused by A. fumigatus. From Public Health Image Library (PHIL). ^[3]
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  Histopathology of aspergillosis of the lung of a caged sulfur-crested cockatoo caused by Aspergillus fumigatus. From Public Health Image Library (PHIL). ^[3]