Autoimmune hemolytic anemia history and symptoms

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shyam Patel [2], Irfan Dotani

Patients with autoimmune hemolytic anemia have a gradual onset of fatigue and can develop shortness of breath and decreased exercise tolerance. The symptoms of autoimmune hemolytic anemia depend on the severity of the disease.

• Patients will usually have report a gradual onset of fatigue.

• Patients may be asymptomatic if the anemia is mild.

Common symptoms of autoimmune hemolytic anemia include:

• Fatigue (feeling weak or tired more often than usual)
• Decreased exercise tolerance
• Headaches
• Problems concentrating or thinking

Symptoms of severe anemia may include:^[1]

• Blue color to the sclera
• Brittle nails
• Light-headedness upon standing
• Pale skin color (pallor)
• Shortness of breath
• Sore tongue
• Palpitations
• Angina
• Abdominal pain (from splenomegaly)

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