Autoimmune hepatitis causes

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Manpreet Kaur, MD [2], Aditya Govindavarjhulla, M.B.B.S. [3]

Overview

Autoimmune hepatitis may be caused by the Drugs like minocycline, nitrofurantoin, hydralazine, methyldopa, statins, fenofibrate, interferon, infliximab, etanercept, viral infections e.g measles virus, EB virus, CMV and hepatitis A, B, C, D, E and if there is the history of other autoimmune diseases e.g graves disease, inflammatory bowel disease, rheumatoid arthritis, scleroderma, Sjogren syndrome, systemic lupus erythematosus, thyroiditis, type 1 diabetes, ulcerative colitis.

Causes

Common Causes

Drugs ^[1]
History of viral infections:
- Measles viruse
- Cytomegalovirus
- Epstein–Barr virus
- Hepatitis A, B, C, D, E.
History of autoimmune disease:^[2]

Causes by Organ System

Cardiovascular	No underlying causes
Chemical / poisoning	Morinda citrifolia (Noni juice), Dai-saiko-to ^[3], Germander, Herbal compounds, Toxic mushrooms (cyclopeptides)
Dermatologic	Scleroderma, Systemic lupus erythematosus
Drug Side Effect	3,4-methylenedioxymetamphetamine, Alpha interferon, Beta interferon, Methyldopa, Minocycline , Ecstasy, Artorvastatin, Atomexitine , Carboxymethyl cellulose , Clometacine ^[4], Diclofenac , Dioctyl sodium sulfosuccinate, Doxycycline, Etanercept, Fenofibrate, Hydralazine, Infliximab, Interferon , Nitrofurantoin, Oxyphenisatin, Papaverine,Peginterferon Beta-1a,Pemoline,Phenprocoumon, Pyrazinamide, Rifampin, Rosuvastatin, Simvastatin , Twinrix
Ear Nose Throat	No underlying causes
Endocrine	Graves disease, Polyendocrine deficiency syndrome type 1, Thyroiditis, Type 1 diabetes
Environmental	No underlying causes
Gastroenterologic	Inflammatory bowel disease, Ulcerative colitis
Genetic	No underlying causes
Hematologic	No underlying causes
Iatrogenic	No underlying causes
Infectious Disease	Measles viruse, Cytomegalovirus, and Epstein–Barr virus
Musculoskeletal / Ortho	Rheumatoid arthritis,
Neurologic	No underlying causes
Nutritional / Metabolic	No underlying causes
Obstetric/Gynecologic	No underlying causes
Oncologic	No underlying causes
Opthalmologic	Grave’s disease, Sjogren syndrome
Overdose / Toxicity	No underlying causes
Psychiatric	No underlying causes
Pulmonary	No underlying causes
Renal / Electrolyte	No underlying causes
Rheum / Immune / Allergy	Rheumatoid arthritis, Graves disease, Inflammatory bowel disease, Polyendocrine deficiency syndrome type 1, Scleroderma, Sjogren syndrome, Systemic lupus erythematosus, Thyroiditis, Type 1 diabetes, Ulcerative colitis
Sexual	No underlying causes
Trauma	No underlying causes
Urologic	No underlying causes
Miscellaneous	No underlying causes

Causes in Alphabetical Order

3,4-methylenedioxymetamphetamine^[5]

Alpha interferon ^[6]

Atorvastatin

Atomexitine

Beta interferon ^[7]

Carboxymethyl cellulose

Clometacine

Dai-saiko-to

Diclofenac

Dioctyl sodium sulfosuccinate

Doxycycline

Ecstasy^[5]

Etanercept

Fenofibrate

Germander ^[8]

Graves disease

Herbal compounds

Hydralazine

Inflammatory bowel disease

Infliximab

Interferon

Methyldopa

Minocycline

Minocycline

Morinda citrifolia (Noni juice)

Nitrofurantoin

Oxyphenisatin ^[9]

Peginterferon Beta-1a

Papaverine

Pemoline

Phenprocoumon ^[10]

Polyendocrine deficiency syndrome type 1

Pyrazinamide

Rheumatoid arthritis

Rifampin

Rosuvastatin

Scleroderma

Simvastatin

Sjogren syndrome

Systemic lupus erythematosus

Thyroiditis

Toxic mushrooms (cyclopeptides)

Twinrix ^[11]

Type 1 diabetes

Ulcerative colitis

References

↑ “Autoimmune Hepatitis”. Retrieved 2013-01-02.
↑ “Autoimmune hepatitis – PubMed Health”. Retrieved 2013-01-02.
↑ Kamiyama T, Nouchi T, Kojima S, Murata N, Ikeda T, Sato C (1997). “Autoimmune hepatitis triggered by administration of an herbal medicine”. The American Journal of Gastroenterology. 92 (4): 703–4. PMID 9128330. Unknown parameter |month= ignored (help); |access-date= requires |url= (help)
↑ Hillon P, Bedenne L, Piard F, Regis P (1988). “Clometacine-induced hepatitis”. Digestive Diseases and Sciences. 33 (8): 1045–6. PMID 3391074. Unknown parameter |month= ignored (help); |access-date= requires |url= (help)
↑ ^5.0 ^5.1 Khakoo SI, Coles CJ, Armstrong JS, Barry RE (1995). “Hepatotoxicity and accelerated fibrosis following 3,4-methylenedioxymetamphetamine (“ecstasy”) usage”. Journal of Clinical Gastroenterology. 20 (3): 244–7. PMID 7797836. Unknown parameter |month= ignored (help)
↑ Ariad S, Song E, Cohen R, Bezwoda WR (1992). “Interferon-alpha induced autoimmune hepatitis in a patient with Philadelphia chromosome-positive chronic myeloid leukemia with cytogenetically normal T lymphocytes”. Molecular Biotherapy. 4 (3): 139–42. PMID 1445668. Unknown parameter |month= ignored (help)
↑ “INTERFERON”.
↑ Poon WT, Chau TL, Lai CK, Tse KY, Chan YC, Leung KS, Chan YW (2008). “Hepatitis induced by Teucrium viscidum”. Clinical Toxicology (Philadelphia, Pa.). 46 (9): 819–22. doi:10.1080/15563650701739590. PMID 18608288. Retrieved 2013-01-02. Unknown parameter |month= ignored (help)
↑ Teh LB, Chong R, Ho JM, Ong YY (1988). “Oxyphenisatin induced chronic active hepatitis–a potential health hazard in Singapore”. Singapore Medical Journal. 29 (5): 508–12. PMID 3241981. Unknown parameter |month= ignored (help); |access-date= requires |url= (help)
↑ Schimanski CC, Burg J, Möhler M, Höhler T, Kanzler S, Otto G, Galle PR, Lohse AW (2004). “Phenprocoumon-induced liver disease ranges from mild acute hepatitis to (sub-) acute liver failure”. Journal of Hepatology. 41 (1): 67–74. doi:10.1016/j.jhep.2004.03.010. PMID 15246210. Retrieved 2013-01-02. Unknown parameter |month= ignored (help)
↑ Van Herck K, Leroux-Roels G, Van Damme P, Srinivasa K, Hoet B (2007). “Ten-year antibody persistence induced by hepatitis A and B vaccine (Twinrix) in adults”. Travel Medicine and Infectious Disease. 5 (3): 171–5. doi:10.1016/j.tmaid.2006.07.003. PMID 17448944. Unknown parameter |month= ignored (help); |access-date= requires |url= (help)

Template:WS Template:WH

[urlAutoimmune_Hepatitis-1] “Autoimmune Hepatitis”. Retrieved 2013-01-02.

[urlAutoimmune_hepatitis_-_PubMed_Health-2] “Autoimmune hepatitis – PubMed Health”. Retrieved 2013-01-02.

[pmid9128330-3] Kamiyama T, Nouchi T, Kojima S, Murata N, Ikeda T, Sato C (1997). “Autoimmune hepatitis triggered by administration of an herbal medicine”. The American Journal of Gastroenterology. 92 (4): 703–4. PMID 9128330. Unknown parameter |month= ignored (help); |access-date= requires |url= (help)

[pmid3391074-4] Hillon P, Bedenne L, Piard F, Regis P (1988). “Clometacine-induced hepatitis”. Digestive Diseases and Sciences. 33 (8): 1045–6. PMID 3391074. Unknown parameter |month= ignored (help); |access-date= requires |url= (help)

[pmid7797836-5] 5.0 ^5.1 Khakoo SI, Coles CJ, Armstrong JS, Barry RE (1995). “Hepatotoxicity and accelerated fibrosis following 3,4-methylenedioxymetamphetamine (“ecstasy”) usage”. Journal of Clinical Gastroenterology. 20 (3): 244–7. PMID 7797836. Unknown parameter |month= ignored (help)

[pmid1445668-6] Ariad S, Song E, Cohen R, Bezwoda WR (1992). “Interferon-alpha induced autoimmune hepatitis in a patient with Philadelphia chromosome-positive chronic myeloid leukemia with cytogenetically normal T lymphocytes”. Molecular Biotherapy. 4 (3): 139–42. PMID 1445668. Unknown parameter |month= ignored (help)

[urlINTERFERON-7] “INTERFERON”.

[pmid18608288-8] Poon WT, Chau TL, Lai CK, Tse KY, Chan YC, Leung KS, Chan YW (2008). “Hepatitis induced by Teucrium viscidum”. Clinical Toxicology (Philadelphia, Pa.). 46 (9): 819–22. doi:10.1080/15563650701739590. PMID 18608288. Retrieved 2013-01-02. Unknown parameter |month= ignored (help)

[pmid3241981-9] Teh LB, Chong R, Ho JM, Ong YY (1988). “Oxyphenisatin induced chronic active hepatitis–a potential health hazard in Singapore”. Singapore Medical Journal. 29 (5): 508–12. PMID 3241981. Unknown parameter |month= ignored (help); |access-date= requires |url= (help)

[pmid15246210-10] Schimanski CC, Burg J, Möhler M, Höhler T, Kanzler S, Otto G, Galle PR, Lohse AW (2004). “Phenprocoumon-induced liver disease ranges from mild acute hepatitis to (sub-) acute liver failure”. Journal of Hepatology. 41 (1): 67–74. doi:10.1016/j.jhep.2004.03.010. PMID 15246210. Retrieved 2013-01-02. Unknown parameter |month= ignored (help)

[pmid17448944-11] Van Herck K, Leroux-Roels G, Van Damme P, Srinivasa K, Hoet B (2007). “Ten-year antibody persistence induced by hepatitis A and B vaccine (Twinrix) in adults”. Travel Medicine and Infectious Disease. 5 (3): 171–5. doi:10.1016/j.tmaid.2006.07.003. PMID 17448944. Unknown parameter |month= ignored (help); |access-date= requires |url= (help)

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