Autoimmune hepatitis risk factors
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Manpreet Kaur, MD [2]
Overview
Common risk factors in the development of autoimmune hepatitis include female gender, Genetic predisposition associated with HLA-DR3 and HLA-DR4, and history of other autoimmune hepatitis eg thyroiditis, type 1 diabetes, ulcerative colitis, celiac disease, and rheumatoid arthritis.
Risk Factors
Common Risk Factors
Common risk factors in the development of autoimmune hepatitis include:
- Females:
- Autoimmune hepatitis is more common in young females.
- Genetic predisposition:[1]
- History of another autoimmune disease:[2]
- Autoimmune diseases, including thyroiditis, type 1 diabetes, ulcerative colitis, celiac disease, and rheumatoid arthritis.
Less Common Risk Factors
Less common risk factors in the development of Autoimmune hepatitis include:
- A history of viral infections:[3][4]
- Autoimmune hepatitis is common who are infected with the measles, herpes simplex or epstein-Barr virus and hepatitis A, B or C infection in the past.
- History of drug intake:[5]
- minocycline, nitrofurantoin, hydralazine, methyldopa statins, fenofibrate, interferon, infliximab, etanercept increases the risk of autoimmune hepatitis.
References
- ↑ Donaldson PT (2004). “Genetics of autoimmune and viral liver diseases; understanding the issues”. J. Hepatol. 41 (2): 327–32. doi:10.1016/j.jhep.2004.06.001. PMID 15288484.
- ↑ “Autoimmune hepatitis – PubMed Health”. Retrieved 2013-01-02.
- ↑ Vento S, Cainelli F (2004). “Is there a role for viruses in triggering autoimmune hepatitis?”. Autoimmun Rev. 3 (1): 61–9. doi:10.1016/S1568-9972(03)00053-3. PMID 14871651.
- ↑ Huppertz HI, Treichel U, Gassel AM, Jeschke R, Meyer zum Büschenfelde KH (1995). “Autoimmune hepatitis following hepatitis A virus infection”. J. Hepatol. 23 (2): 204–8. PMID 7499793.
- ↑ Björnsson E, Talwalkar J, Treeprasertsuk S, Kamath PS, Takahashi N, Sanderson S, Neuhauser M, Lindor K (2010). “Drug-induced autoimmune hepatitis: clinical characteristics and prognosis”. Hepatology. 51 (6): 2040–8. doi:10.1002/hep.23588. PMID 20512992.
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