Autoimmune lymphoproliferative syndrome primary prevention

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Sharmi Biswas, M.B.B.S

An autoimmune lymphoproliferative syndrome(ALPS) is a genetic disorder that is inherited in most cases. So, there are no primary prevention guidelines so far.

For the individuals with severe clinical phenotypes as ALPS-FAS which is caused by biallelic pathogenic variants, having severe refractory cytopenias developed lymphoma, or having complications from immunosuppressive therapy require bone marrow transplant which might be the only curative treatment.^[1]