B-cell lymphoma classification
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Adnan Ezici, M.D[2]
Overview
B-cell lymphomas include both Hodgkin’s lymphomas and most Non-Hodgkin lymphomas. Hodgkin’s lymphoma may be classified according to the World Health Organisation classification system into 2 groups: nodular lymphocyte-predominant Hodgkin lymphoma and classical Hodgkin lymphoma (includes nodular sclerosis classical Hodgkin lymphoma, lymphocyte-rich classical Hodgkin lymphoma, mixed cellularity classical Hodgkin lymphoma, and lymphocyte-depleted classical Hodgkin lymphoma). Non-Hodgkin lymphomas may be classified into several subtypes based on the World Health Organisation classification system.
Classification
B-cell lymphomas include both Hodgkin’s lymphomas and most Non-Hodgkin lymphomas.
- Hodgkin’s lymphoma may be classified according to the World Health Organisation classification system into 2 groups:[1]
- Nodular lymphocyte predominant Hodgkin lymphoma
- Classical Hodgkin lymphoma (includes 4 subtypes)
- Nodular sclerosis classical Hodgkin lymphoma
- Lymphocyte-rich classical Hodgkin lymphoma
- Mixed cellularity classical Hodgkin lymphoma
- Lymphocyte-depleted classical Hodgkin lymphoma
- Non-Hodgkin lymphoma may be classified according to the World Health Organisation classification system into 2 groups including B-cell neoplasms, and T-cell and putative NK-cell neoplasms. B-cell neoplasms may further be classified according to the World Health Organisation into: [1][2][3]
- Chronic lymphocytic leukemia/small lymphocytic lymphoma
- Monoclonal B-cell lymphocytosis
- B-cell prolymphocytic leukemia
- Splenic marginal zone lymphoma
- Hairy cell leukemia
- Splenic B-cell lymphoma/leukemia, unclassifiable
- Splenic diffuse red pulp small B-cell lymphoma
- Hairy cell leukemia-variant
- Lymphoplasmacytic lymphoma
- Monoclonal gammopathy of undetermined significance (MGUS), IgM
- μ heavy-chain disease
- ɣ heavy-chain disease
- a heavy-chain disease
- Monoclonal gammopathy of undetermined significance (MGUS), IgG/A
- Plasma cell myeloma
- Solitary plasmacytoma of bone
- Extraosseous plasmacytoma
- Monoclonal immunoglobulin deposition diseases
- Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma)
- Nodal marginal zone lymphoma
- Pediatric nodal marginal zone lymphoma
- Follicular lymphoma
- In situ follicular neoplasia
- Duodenal-type follicular lymphoma
- Pediatric-type follicular lymphoma
- Large B-cell lymphoma with IRF4 rearrangement
- Primary cutaneous follicle center lymphoma
- Mantle cell lymphoma
- In situ mantle cell neoplasia
- Diffuse large B-cell lymphoma (DLBCL), not otherwise specified (NOS)
- Germinal center B-cell type
- Activated B-cell type
- T-cell/histiocyte-rich large B-cell lymphoma
- Primary DLBCL of the central nervous system (CNS)
- Primary cutaneous DLBCL, leg type
- EBV (+) DLBCL, not otherwise specified (NOS)
- EBV (+) mucocutaneous ulcer
- DLBCL associated with chronic inflammation
- Lymphomatoid granulomatosis
- Primary mediastinal (thymic) large B-cell lymphoma
- Intravascular large B-cell lymphoma
- ALK (+) large B-cell lymphoma
- Plasmablastic lymphoma
- Primary effusion lymphoma
- HHV8 (+) DLBCL, not otherwise specified (NOS)
- Burkitt lymphoma
- Burkitt-like lymphoma with 11q aberration
- High-grade B-cell lymphoma, with MYC and BCL2 and/or BCL6 translocations
- High-grade B-cell lymphoma, not otherwise specified (HGBL, NOS)
- B-cell lymphoma, unclassifiable, with features intermediate between DLBCL and classical Hodgkin lymphoma
- Non-Hodgkin lymphoma may be classified according to rate of growth into 2 subtypes:
- Aggresive (high-grade)
- Indolent (low-grade)
Most common
Five account for nearly three out of four patients with non-Hodgkin lymphoma:[4]
- Diffuse large B cell lymphoma
- Follicular lymphoma
- Mucosa-Associated Lymphatic Tissue lymphoma (MALT)
- Small cell lymphocytic lymphoma (overlaps with Chronic lymphocytic leukemia)
- Mantle cell lymphoma (MCL)
Rare
The remaining forms are much less common:[4]
- Burkitt lymphoma
- Mediastinal large B cell lymphoma
- Waldenström macroglobulinemia
- Nodal marginal zone B cell lymphoma (NMZL)
- Splenic marginal zone lymphoma (SMZL)
- Extranodal marginal zone B cell lymphoma
- Intravascular large B cell lymphoma
- Primary effusion lymphoma
- Lymphomatoid granulomatosis
- T cell/histiocyte-rich large B-cell lymphoma
- Primary central nervous system lymphoma
- Primary cutaneous diffuse large B-cell lymphoma, leg type (Primary cutaneous DLBCL, leg type)
- EBV positive diffuse large B-cell lymphoma of the elderly
- Diffuse large B-cell lymphoma associated with inflammation
- Intravascular large B-cell lymphoma
- ALK-positive large B-cell lymphoma
- Plasmablastic lymphoma
- Large B-cell lymphoma arising in HHV8-associated multicentric Castleman’s disease
- B-cell lymphoma, unclassifiable with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma
- B-cell lymphoma, unclassifiable with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma
References
- ↑ 1.0 1.1 Swerdlow SH, Campo E, Pileri SA, Harris NL, Stein H, Siebert R, Advani R, Ghielmini M, Salles GA, Zelenetz AD, Jaffe ES (May 2016). “The 2016 revision of the World Health Organization classification of lymphoid neoplasms”. Blood. 127 (20): 2375–90. doi:10.1182/blood-2016-01-643569. PMC 4874220. PMID 26980727.
- ↑ National Cancer Institute. Physician Data Query Database 2015.http://www.cancer.gov/publications/pdq
- ↑ Perry AM, Diebold J, Nathwani BN, MacLennan KA, Müller-Hermelink HK, Bast M, Boilesen E, Armitage JO, Weisenburger DD (October 2016). “Non-Hodgkin lymphoma in the developing world: review of 4539 cases from the International Non-Hodgkin Lymphoma Classification Project”. Haematologica. 101 (10): 1244–1250. doi:10.3324/haematol.2016.148809. PMC 5046654. PMID 27354024.
- ↑ 4.0 4.1 “The Lymphomas” (PDF). The Leukemia & Lymphoma Society. May 2006. pp. p. 12. Retrieved 2008-04-07.
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