Back pain laboratory findings

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Zehra Malik, M.B.B.S [2]

Overview

There are no diagnostic laboratory findings associated with back pain. However, to investigate the underlying cause of back pain it is crucial to look for the following, complete blood count (CBC), erythrocyte sedimentation rate, C-reactive protein, HLA-B27, antinuclear antibody (ANA), rheumatoid factor, lactate dehydrogenase (LDH), uric acid.

Laboratory Findings

There are no diagnostic laboratory findings associated with back pain. However, to investigate the underlying cause of back pain it is crucial to test for the following:

Laboratory Test	Pathology Suspected
Complete blood count (CBC)	Infections, inflammation
Erythrocyte sedimentation rate	Infection, inflammation, arthritis^[1]
C-reactive protein	Inflammation, arthritis^[2]
HLA-B27	Ankylosing spondylitis, reactive arthritis^[3]
Rheumatoid factor	Rheumatoid arthritis^[4]
Lactate dehydrogenase (LDH)	Rapid marrow turnover^[5]
Uric acid	Rapid marrow turnover^[5]

References

↑ Harrison M (2015). “Erythrocyte sedimentation rate and C-reactive protein”. Aust Prescr. 38 (3): 93–4. doi:10.18773/austprescr.2015.034. PMC 4653962. PMID 26648629.
↑ Sproston NR, Ashworth JJ (2018). “Role of C-Reactive Protein at Sites of Inflammation and Infection”. Front Immunol. 9: 754. doi:10.3389/fimmu.2018.00754. PMC 5908901. PMID 29706967.
↑ McMichael A, Bowness P (2002). “HLA-B27: natural function and pathogenic role in spondyloarthritis”. Arthritis Res. 4 Suppl 3: S153–8. doi:10.1186/ar571. PMC 3240147. PMID 12110134.
↑ Ingegnoli F, Castelli R, Gualtierotti R (2013). “Rheumatoid factors: clinical applications”. Dis Markers. 35 (6): 727–34. doi:10.1155/2013/726598. PMC 3845430. PMID 24324289.
↑ ^5.0 ^5.1 Ejaz AA, Pourafshar N, Mohandas R, Smallwood BA, Johnson RJ, Hsu JW (2015). “Uric acid and the prediction models of tumor lysis syndrome in AML”. PLoS One. 10 (3): e0119497. doi:10.1371/journal.pone.0119497. PMC 4361475. PMID 25775138.

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[pmid26648629-1] Harrison M (2015). “Erythrocyte sedimentation rate and C-reactive protein”. Aust Prescr. 38 (3): 93–4. doi:10.18773/austprescr.2015.034. PMC 4653962. PMID 26648629.

[pmid29706967-2] Sproston NR, Ashworth JJ (2018). “Role of C-Reactive Protein at Sites of Inflammation and Infection”. Front Immunol. 9: 754. doi:10.3389/fimmu.2018.00754. PMC 5908901. PMID 29706967.

[pmid12110134-3] McMichael A, Bowness P (2002). “HLA-B27: natural function and pathogenic role in spondyloarthritis”. Arthritis Res. 4 Suppl 3: S153–8. doi:10.1186/ar571. PMC 3240147. PMID 12110134.

[pmid24324289-4] Ingegnoli F, Castelli R, Gualtierotti R (2013). “Rheumatoid factors: clinical applications”. Dis Markers. 35 (6): 727–34. doi:10.1155/2013/726598. PMC 3845430. PMID 24324289.

[pmid25775138-5] 5.0 ^5.1 Ejaz AA, Pourafshar N, Mohandas R, Smallwood BA, Johnson RJ, Hsu JW (2015). “Uric acid and the prediction models of tumor lysis syndrome in AML”. PLoS One. 10 (3): e0119497. doi:10.1371/journal.pone.0119497. PMC 4361475. PMID 25775138.

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