Bartter syndrome medical therapy

Main article: Bartter syndrome

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Tayyaba Ali, M.D.[2]

Prostaglandin synthetase inhibitors suppress the production of prostaglandin. Potassium chloride supplements are given for hypokalemia. Spironolactone, Amiloride, Triamterene, Angiotensin-converting enzyme (ACE) inhibitors, Nonsteroidal drug anti-inflammatory drugs (NSAID) are given to patients for the treatment of Bartter syndrome. Growth hormone (GH) is given for growth retardation. Calcium or magnesium supplements are given for muscle spasm and tetany.

• Prostaglandin synthetase inhibitors suppress the production of prostaglandin. This corrects all the chemical features of the syndrome except the urinary loss of potassium.^[1]
• Hypokalemia should be treated. Potassium chloride supplements are preferred salt because of the coexisting chloride deficiencies in these patients.
• Spironolactone, aldosterone antagonist.
• Amiloride reduces potassium and hydrogen excretion, by inhibiting epithelial sodium channels (ENaC).
• Triamterene decreases calcium excretion and increases magnesium loss.
• Angiotensin-converting enzyme (ACE) inhibitors, such as captopril, enalapril and lisinopril.
• Nonsteroidal drug anti-inflammatory drugs (NSAID) such as indomethacin and naproxen which decrease the activity of the enzyme cyclo-oxygenase (COX) which increases prostaglandin synthesis.
• Growth hormone (GH) for growth retardation.
• Calcium or magnesium supplements in the presence of muscle spasm and tetany.^[2]

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