Blue rubber bleb nevus syndrome medical therapy

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Vamsikrishna Gunnam M.B.B.S [2]

The mainstay of treatment for blue rubber bleb nevus syndrome is interferon-beta, octreotide, iron supplementation and blood transfusions.

• Pharmacologic medical therapies for blue rubber bleb nevus syndrome include:^{[1][2][3][4][5]}
  • Preferred regimen (1): Interferon-beta, 1.2 mg/m²/day for 2 month
  • Preferred regimen (2): Octreotide, 5.7 microg/kg subcutaneously twice daily for 4 weeks^[6]
  • Preferred regimen (3): Sirolimus,1.2 mg/m²/day for 2 months ^[7]
  • Preferred regimen (4): Iron supplementation
  • Preferred regimen (5): Blood transfusions
  • Preferred regimen (6): Corticosteroids
  • Preferred regimen (7): Propranolol, 40 mg twice daily; titrate weekly as needed based on patient response
  • Preferred regimen (8): Thalidomide

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