Buerger's disease laboratory findings

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Hadeel Maksoud M.D.[2]

Overview

There are no diagnostic laboratory findings associated with Buerger’s disease. Lab testing is done to exclude other vasculitides, such as lupus, scleroderma and mixed connective tissue disease.

Laboratory Findings

There are no diagnostic laboratory findings associated with Buerger’s disease.
Laboratory testing is performed to exclude other pathologies, and include:^[1]^[2]^[3]
- Acute phase reactants that indicate an active inflammatory process:
  - Erythrocyte sedimentation rate
  - C-reactive protein
- Immunologic panel to rule out autoimmune disease:
  - Antinuclear antibody
  - Rheumatoid factor
  - Anticentromere antibody
  - Antiphospholipid antibody
  - Serum creatinine
  - Complement
  - SCL-70
- To rule out hypercoagulability:
  - Complete blood count
  - Liver function test
  - PT, PTT and INR
  - Antiphospholipid antibodies
  - Anticardiolipin antibodies
  - Protein C and S
  - Antithrombin III
  - Factor V Leiden
  - Prothrombin gene mutation
- Toxicology screen
- Others
  - Fasting glucose
  - Urine analysis

References

↑ Olin JW (September 2000). “Thromboangiitis obliterans (Buerger’s disease)”. N. Engl. J. Med. 343 (12): 864–9. doi:10.1056/NEJM200009213431207. PMID 10995867.
↑ Maslowski L, McBane R, Alexewicz P, Wysokinski WE (2002). “Antiphospholipid antibodies in thromboangiitis obliterans”. Vasc Med. 7 (4): 259–64. doi:10.1191/1358863x02vm452oa. PMID 12710840.
↑ Piazza G, Creager MA (April 2010). “Thromboangiitis obliterans”. Circulation. 121 (16): 1858–61. doi:10.1161/CIRCULATIONAHA.110.942383. PMC 2880529. PMID 20421527.

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[pmid10995867-1] Olin JW (September 2000). “Thromboangiitis obliterans (Buerger’s disease)”. N. Engl. J. Med. 343 (12): 864–9. doi:10.1056/NEJM200009213431207. PMID 10995867.

[pmid12710840-2] Maslowski L, McBane R, Alexewicz P, Wysokinski WE (2002). “Antiphospholipid antibodies in thromboangiitis obliterans”. Vasc Med. 7 (4): 259–64. doi:10.1191/1358863x02vm452oa. PMID 12710840.

[pmid20421527-3] Piazza G, Creager MA (April 2010). “Thromboangiitis obliterans”. Circulation. 121 (16): 1858–61. doi:10.1161/CIRCULATIONAHA.110.942383. PMC 2880529. PMID 20421527.

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