C8 complex

Complement component 8 is a protein involved in the complement system. It is part of the membrane attack complex (MAC).

A hereditary deficiency of C8 can result in increased susceptibility to Neisseria infections, such as meningitis and gonorrhea.

C8 is a heterotrimer; it consists of three different subunits. These are called C8 alpha, beta and gamma chains, encoded by the genes C8A, C8B and C8G respectively.

1.J Biol Chem. 2011 May 20;286(20):17585-92. Epub 2011 Mar 25. Figure created in Pymol

• Complement+C8 at the US National Library of Medicine Medical Subject Headings (MeSH)

The crystal structure is now in the PDB, PDB ID 3OJY.