Decay accelerating factor

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Decay accelerating factor (CD55) is a 70 kDa membrane protein that regulates the complement system on the cell surface. It prevents the assembly of the C3bBb complex (the C3-convertase of the alternative pathway) or accelerates the disassembly of preformed convertase, thus blocking the formation of the membrane attack complex.

This glycoprotein is broadly distributed among hematopoietic and non-hematopoietic cells. It is a determinant for the Cromer blood group system.

DAF is not expressed on paroxysmal nocturnal hemoglobinuria III (markedly abnormal) RBCs; however, this deficiency is not the cause of PNH.

• List of human clusters of differentiation

• Decay-Accelerating+Factor at the US National Library of Medicine Medical Subject Headings (MeSH)
• Cromer blood group system at BGMUT, Blood Group Antigen Gene Mutation Database at NCBI, NIH

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