Cardiac allograft vasculopathy optical coherence tomography

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aarti Narayan, M.B.B.S [2]; Raviteja Guddeti, M.B.B.S. [3]

Overview

In 2010, U.S FDA approved coronary optical cohorence tomography (OCT) as a new catheter based intra-vascular imaging modality with a resolution higher than intravascular ultrasound (IVUS). OCT uses near infra-red light and constructs images from the reflected light which is in the same phase (i.e cohorent) with the emitted light. This eliminated the interference from scattered light, thereby producing images with higher resolution.

Coronary Optical Cohorence Tomography

Advantages

Allows rapid imaging of coronaries with a higher radial resolution.
Detects more subtle changes in the intima-media thickness compared to IVUS in patients with early CAV.
Accurate plaque characterization^[1].

Limitations

Complete blood washout from the coronaries is necessary to obtain good quality images.
Deep tissue penetration is not as good as IVUS^[1].

References

↑ ^1.0 ^1.1 Khandhar SJ, Yamamoto H, Teuteberg JJ, Shullo MA, Bezerra HG, Costa MA; et al. (2013). “Optical coherence tomography for characterization of cardiac allograft vasculopathy after heart transplantation (OCTCAV study)”. J Heart Lung Transplant. 32 (6): 596–602. doi:10.1016/j.healun.2013.02.005. PMID 23499356.

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[pmid23499356-1] 1.0 ^1.1 Khandhar SJ, Yamamoto H, Teuteberg JJ, Shullo MA, Bezerra HG, Costa MA; et al. (2013). “Optical coherence tomography for characterization of cardiac allograft vasculopathy after heart transplantation (OCTCAV study)”. J Heart Lung Transplant. 32 (6): 596–602. doi:10.1016/j.healun.2013.02.005. PMID 23499356.

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