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Celiac disease causes

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Furqan M M. M.B.B.S[2]

Overview

The common causes of celiac disease are autoantibodies to gluten and certain genetic factors.

Causes

The common causes of celiac disease are autoantibodies to gluten and certain genetic factors.[1][2]

Common Causes

Celiac disease is usually caused by:

  • Autoantibodies against gluten which is found in:

Genetic Causes

  • Celiac disease is linked to the HLA genes usually HLA DQ2 and HLA DQ8.
    • CELIAC1 (6p21)
  • Non-HLA genes are also thought to be related to celiac disease:
    • CELIAC2 (5q31-33)
    • CELIAC3 (2q33)
    • CELIAC4 (19p13·1)

References

  1. ↑ Di Sabatino A, Corazza GR (2009). “Coeliac disease”. Lancet. 373 (9673): 1480–93. doi:10.1016/S0140-6736(09)60254-3. PMID 19394538.
  2. ↑ Heap GA, van Heel DA (2009). “Genetics and pathogenesis of coeliac disease”. Semin. Immunol. 21 (6): 346–54. doi:10.1016/j.smim.2009.04.001. PMID 19443237.

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