Cerebral aneurysm future or investigational therapies

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ;Associate Editor(s)-in-Chief: Anika Zahoor M.D.[2]

Overview:

For future, researchers are currently hitting two main therapies cell & drug therapy

Investigational Therapies

In order to get cure from Cerebral Aneurysm, the more focus should be on reconstruction of vascular wall with normal endothelialization.

Currently, there are two main classes of pharmacology, used for this purpose.

Cell Therapies:

Endothelial Progenitor cells (EPCs)
Mesenchymal stem cells (MSCs)
Vascular smooth muscle cells (VSMs)
Fibroblasts

Drug Therapies:

MCP-1 Inhibitors
ACE inhibitors
TNF-alpha Inhibitors

Future Perspectives:

The Subarachnoid Hemorrhage is consider as a major cause of Cerebral Aneurysm. The main goal for management of cerebral aneurysm is prevention of rupture or re-rupture.

The main management for CA is currently surgical procedures which only modify morphological aspects of aneurysm and cannot completely prevent from re-rupture.

Therefore, it is necessary to develop more effective and less risky treatments that are also fall in the line of cost-effectiveness.

References

Aoki T, Nozaki K. Preemptive Medicine for Cerebral Aneurysms. Neurol Med Chir (Tokyo). 2016 Sep 15;56(9):552-68. doi: 10.2176/nmc.st.2016-0063. Epub 2016 Apr 6. PMID: 27053328; PMCID: PMC5027238.