Cheyne-Stokes respiration historical perspective

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Sleep disordered breathing was first described by Cheyne in 1818 in a 60 year old obese man with heart failure. In 1854, Stokes described a similar pattern of breathing that eventually culminated in apnea. The term Cheyne-Stokes respiration (CSR) describes a pattern of breathing with a crescendo – decrescendo variation in tidal volume separated by periods of central apnea or hypopnea.

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