Chlorproethazine
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Chlorproethazine is an antipsychotic.
Synthesis
Chlorproethazine can be synthesized from a diphenylsulfide derivative. The general scheme is sufficiently flexible to permit the interchange of the order of some of the steps.
Thus alkylation of aniline thioether () with 3-chloro-1-diethylaminopropane leads to the intermediate (). Ring closure as above by nucleophilic aromatic displacement leads to the antipsychotic drug chlorproethazine.[1]
References
- ↑ Buisson, P.; Gailliot, P.; 1956, Template:US Patent
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