Cholesterol emboli syndrome other diagnostic studies

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Biopsy of lesions can definitely establish the diagnosis of cholesterol emboli syndrome.^[1]^[2]
- On biposy from skin, muscle, kidney or gastrointestinal tract, [[cholesterol emboli syndrome] is characterized by cholesterol crystals.^[3]^[4]
- Biopsy of affected organs shows characteristic changes in about half to 75% the clinically diagnosed cases.
- Biopsy of skin lesions is often revealing in patients with cutaneous involvement.
- Transverse sections of affected arterioles, show occlusion of the lumen by biconvex needle-shaped cholesterol crystals, which dissolve during histologic processing to leave clefts, surrounded by fibrin and platelet thrombi, sometimes in association with foreign-body giant cells and intimal thickening.

↑ Jucgla, Anna; Moreso, Francesc; Muniesa, Cristina; Moreno, Abelardo; Vidaller, Antonio (2006). “Cholesterol embolism: Still an unrecognized entity with a high mortality rate”. Journal of the American Academy of Dermatology. 55 (5): 786–793. doi:10.1016/j.jaad.2006.05.012. ISSN 0190-9622.
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↑ Paraf, Francois; Jacquot, Christian; Bloch, Francis; Montpreville, Vincent; Bruneval, Patrick (2001). “Cholesterol crystal embolization demonstrated on GI biopsy”. The American Journal of Gastroenterology. 96 (12): 3301–3304. doi:10.1111/j.1572-0241.2001.05329.x. ISSN 0002-9270.