Cholesterolosis of gallbladder pathophysiology

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief:

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• Gallbladder cholecystoses are conditions characterized by the accumulation of cholesterol and other fats in the gallbladder. The two main forms are adenomyomatosis and cholesterolosis.
• Cholesterolosis of gallbladder develops from deposition of triglycerides and cholesterol esters within the lamina propria of gallbladder wall causing mucosal hyperplasia.
• Deposition of cholesterol esters can be diffused or localized.
• Gross appearance of the mucosa of gallbladder wall due to diffuse cholesterolosis is known as “strawberry gallbladder”.
• Cholesterolosis should be differentiated from adenomyomatosis which involves hyperplasia of both mucosa and muscularis propria.^[1]

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