Chromatin target of prmt1
Chromatin target of PRMT1 is a protein that in humans is encoded by the CHTOP gene.[1]
Function
This gene encodes a small nuclear protein that is characterized by a arginine and glycine rich region. The encoded protein may be involved in cell cycle progression. This protein interacts with protein arginine methyltransferases and plays a role in the activation of estradiol-dependent transcription. Alternate splicing results in multiple transcript variants.
References
Further reading
- Zullo AJ, Michaud M, Zhang W, Grusby MJ (May 2009). “Identification of the small protein rich in arginine and glycine (SRAG): a newly identified nucleolar protein that can regulate cell proliferation”. The Journal of Biological Chemistry. 284 (18): 12504–11. doi:10.1074/jbc.M809436200. PMC 2673316. PMID 19254951.
- Chang CT, Hautbergue GM, Walsh MJ, Viphakone N, van Dijk TB, Philipsen S, Wilson SA (February 2013). “Chtop is a component of the dynamic TREX mRNA export complex”. The EMBO Journal. 32 (3): 473–86. doi:10.1038/emboj.2012.342. PMC 3567497. PMID 23299939.
- Teng IF, Wilson SA (2013). “Mapping interactions between mRNA export factors in living cells”. PLOS One. 8 (6): e67676. doi:10.1371/journal.pone.0067676. PMC 3691119. PMID 23826332.
- van Dijk TB, Gillemans N, Stein C, Fanis P, Demmers J, van de Corput M, Essers J, Grosveld F, Bauer UM, Philipsen S (January 2010). “Friend of Prmt1, a novel chromatin target of protein arginine methyltransferases”. Molecular and Cellular Biology. 30 (1): 260–72. doi:10.1128/MCB.00645-09. PMC 2798285. PMID 19858291.
- van Dijk TB, Gillemans N, Pourfarzad F, van Lom K, von Lindern M, Grosveld F, Philipsen S (November 2010). “Fetal globin expression is regulated by Friend of Prmt1”. Blood. 116 (20): 4349–52. doi:10.1182/blood-2010-03-274399. PMC 2993632. PMID 20688955.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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