Chronic lymphocytic leukemia history and symptoms

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]Raviteja Guddeti, M.B.B.S. [3]

Overview

Twenty-five to fifty percent of patients with chronic lymphocytic leukemia are usually asymptomatic with incidental absolute lymphocytosis finding on a routine blood examination. The onset of chronic lymphocytic leukemia is insidious and can present with wide range of symptoms. Symptoms of chronic lymphocytic leukemia include lymph node swelling and “B” symptoms including fever, weight loss, night sweats, fatigue and recurrent bleeding.

History

Although majority of patients with chronic lymphocytic leukemia have non-specific history, a through, detailed history from the patient is necessary. Most of the patients with chronic lymphocytic leukemia are asymptomatic, so they are diagnosed incidentally on a routine blood examination.

Symptoms

Symptoms of chronic lymphocytic leukemia include:^[1]^[2]^[3]

Painless lymph node enlargement (50-90%)
Abdominal pain
“B” symptoms (5-10%):^[1]
- Fever
- Unintentional weight loss
- Muscle wasting
- Generalized weakness/ fatigue
- Anorexia
- Night sweats
Recurrent infections
Recurrent bleeding
Skin lesions^[4]

References

↑ ^1.0 ^1.1 Hallek M, Cheson BD, Catovsky D, Caligaris-Cappio F, Dighiero G, Döhner H, Hillmen P, Keating M, Montserrat E, Chiorazzi N, Stilgenbauer S, Rai KR, Byrd JC, Eichhorst B, O’Brien S, Robak T, Seymour JF, Kipps TJ (June 2018). “iwCLL guidelines for diagnosis, indications for treatment, response assessment, and supportive management of CLL”. Blood. 131 (25): 2745–2760. doi:10.1182/blood-2017-09-806398. PMID 29540348.
↑ Rai KR, Sawitsky A, Cronkite EP, Chanana AD, Levy RN, Pasternack BS (August 1975). “Clinical staging of chronic lymphocytic leukemia”. Blood. 46 (2): 219–34. PMID 1139039.
↑ Kipps TJ, Stevenson FK, Wu CJ, Croce CM, Packham G, Wierda WG, O’Brien S, Gribben J, Rai K (January 2017). “Chronic lymphocytic leukaemia”. Nat Rev Dis Primers. 3: 16096. doi:10.1038/nrdp.2016.96. PMC 5336551. PMID 28102226.
↑ Agnew KL, Ruchlemer R, Catovsky D, Matutes E, Bunker CB (June 2004). “Cutaneous findings in chronic lymphocytic leukaemia”. Br. J. Dermatol. 150 (6): 1129–35. doi:10.1111/j.1365-2133.2004.05982.x. PMID 15214899.

Template:Hematology

Template:WikiDoc Sources

[pmid29540348-1] 1.0 ^1.1 Hallek M, Cheson BD, Catovsky D, Caligaris-Cappio F, Dighiero G, Döhner H, Hillmen P, Keating M, Montserrat E, Chiorazzi N, Stilgenbauer S, Rai KR, Byrd JC, Eichhorst B, O’Brien S, Robak T, Seymour JF, Kipps TJ (June 2018). “iwCLL guidelines for diagnosis, indications for treatment, response assessment, and supportive management of CLL”. Blood. 131 (25): 2745–2760. doi:10.1182/blood-2017-09-806398. PMID 29540348.

[pmid1139039-2] Rai KR, Sawitsky A, Cronkite EP, Chanana AD, Levy RN, Pasternack BS (August 1975). “Clinical staging of chronic lymphocytic leukemia”. Blood. 46 (2): 219–34. PMID 1139039.

[pmid28102226-3] Kipps TJ, Stevenson FK, Wu CJ, Croce CM, Packham G, Wierda WG, O’Brien S, Gribben J, Rai K (January 2017). “Chronic lymphocytic leukaemia”. Nat Rev Dis Primers. 3: 16096. doi:10.1038/nrdp.2016.96. PMC 5336551. PMID 28102226.

[pmid15214899-4] Agnew KL, Ruchlemer R, Catovsky D, Matutes E, Bunker CB (June 2004). “Cutaneous findings in chronic lymphocytic leukaemia”. Br. J. Dermatol. 150 (6): 1129–35. doi:10.1111/j.1365-2133.2004.05982.x. PMID 15214899.

[1]

[2]

[3]

[4]