Churg-Strauss syndrome causes
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Chandrakala Yannam, MD [2]
Overview
The etiology of eosinophilic granulomatosis with polyangiitis is not known. Various allergens, infections, vaccinations and drugs may act as a triggering agents, and are responsible for developing disease through an allergic or autoimmune response. Genetics may also play a role and HLA -DRB4 and IL-10 gene polymorphisms are associated with the development of eosinophilic granulomatosis with polyangiitis.
Causes
Life-threatening Causes
- Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated. There are no life-threatening causes of eosinophilic granulomatosis with polyangiitis, however complications resulting from untreated eosinophilic granulomatosis with polyangiitis are common.
Causes
- The causes for eosinophilic granulomatosis with polyangiitis are not known.[1][2]
- Environmental agents and drugs may be responsibe for development of eosinophilic granulomatosis with polyangiitis through an allergic or autoimmune response.
- Allergens
- Infections
- Vaccinations (eg, influenza)
- Drugs:[3][4][5]
- Leukotriene receptor antagonists/ leukotriene modifying agents (eg, montelukast, zafirlukast)
- Anti IgE antibodies (eg, omalizumab)
- Mesalazine
- Propylthiouracil
- Methimazole
- Exposure to silica
- Cocaine
Genetic Causes
- Eosinophilic granulomatosis with polyangiitis is associated with HLA-DRB1*04 and *07 and with HLA – DRB4.[6]
- Eosinophilic granulomatosis with polyangiitis is also associated with polymorphisms ivolving single nucleotides of interleukin -10 gene.[7]
Causes by Organ System
| Cardiovascular | No underlying causes |
| Chemical/Poisoning | No underlying causes |
| Dental | No underlying causes |
| Dermatologic | No underlying causes |
| Drugs | Leukotriene receptor antagonists (eg, montelukast, zafirlukast), Anti IgE antibodies (eg, omalizumab), Mesalazine, PropylthiouracilMethimazole, silica, Cocaine |
| Ear Nose Throat | No underlying causes |
| Endocrine | No underlying causes |
| Environmental | Allergens, vaccinations |
| Gastroenterologic | No underlying causes |
| Genetic | HLA – DRB4, HLA – DRB1*04 and *07, Interleukin -10 gene single nucleotide polymorphisms |
| Hematologic | No underlying causes |
| Iatrogenic | No underlying causes |
| Infectious Disease | No underlying causes |
| Musculoskeletal/Orthopedic | No underlying causes |
| Neurologic | No underlying causes |
| Nutritional/Metabolic | No underlying causes |
| Obstetric/Gynecologic | No underlying causes |
| Oncologic | No underlying causes |
| Ophthalmologic | No underlying causes |
| Overdose/Toxicity | No underlying causes |
| Psychiatric | No underlying causes |
| Pulmonary | No underlying causes |
| Renal/Electrolyte | No underlying causes |
| Rheumatology/Immunology/Allergy | No underlying causes |
| Sexual | No underlying causes |
| Trauma | No underlying causes |
| Urologic | No underlying causes |
| Miscellaneous | No underlying causes |
Causes in Alphabetical Order
List the causes of the disease in alphabetical order.
References
- ↑ Hellmich B, Ehlers S, Csernok E, Gross WL (2003). “Update on the pathogenesis of Churg-Strauss syndrome”. Clin. Exp. Rheumatol. 21 (6 Suppl 32): S69–77. PMID 14740430.
- ↑ Safran T, Masckauchan M, Maj J, Green L (December 2017). “Wells syndrome secondary to influenza vaccination: A case report and review of the literature”. Hum Vaccin Immunother: 1–3. doi:10.1080/21645515.2017.1417714. PMID 29240526.
- ↑ Puéchal X, Rivereau P, Vinchon F (July 2008). “Churg-Strauss syndrome associated with omalizumab”. Eur. J. Intern. Med. 19 (5): 364–6. doi:10.1016/j.ejim.2007.09.001. PMID 18549941.
- ↑ Gómez-Puerta JA, Gedmintas L, Costenbader KH (October 2013). “The association between silica exposure and development of ANCA-associated vasculitis: systematic review and meta-analysis”. Autoimmun Rev. 12 (12): 1129–35. doi:10.1016/j.autrev.2013.06.016. PMC 4086751. PMID 23820041.
- ↑ Orriols R, Muñoz X, Ferrer J, Huget P, Morell F (January 1996). “Cocaine-induced Churg-Strauss vasculitis”. Eur. Respir. J. 9 (1): 175–7. PMID 8834352.
- ↑ Vaglio A, Martorana D, Maggiore U, Grasselli C, Zanetti A, Pesci A, Garini G, Manganelli P, Bottero P, Tumiati B, Sinico RA, Savi M, Buzio C, Neri TM (September 2007). “HLA-DRB4 as a genetic risk factor for Churg-Strauss syndrome”. Arthritis Rheum. 56 (9): 3159–66. doi:10.1002/art.22834. PMID 17763415.
- ↑ Wieczorek S, Hellmich B, Arning L, Moosig F, Lamprecht P, Gross WL, Epplen JT (June 2008). “Functionally relevant variations of the interleukin-10 gene associated with antineutrophil cytoplasmic antibody-negative Churg-Strauss syndrome, but not with Wegener’s granulomatosis”. Arthritis Rheum. 58 (6): 1839–48. doi:10.1002/art.23496. PMID 18512809.
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