Complex regional pain syndrome causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

The cause of complex regional pain syndrome is currently unknown. Precipitating factors include underlying illnesses (especially vascular disease, an underlying rheumatic condition, a hidden infection or a coagulopathy in RSD cases), orthopedic injury, and surgery.

The cause of this syndrome is currently unknown. Precipitating factors include underlying illness (especially vascular disease, an underlying rheumatic condition, a hidden infection or a coagulopathy in RSD cases), orthopedic injury and surgery. Although there are documented cases that have no identifiable injury to the original site in almost all cases of RSD there was an underlying event or injury.

Possible causes of CRPS:

• Injury directly to a nerve
• Injury or infection in an arm or leg

Rarely, sudden illnesses such as a heart attack or stroke can cause CSPS. The condition can sometimes appear without obvious injury to the affected limb.

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