Congenital diaphragmatic hernia risk factors

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Arooj Naz, M.B.B.S

Unlike other hernias that develop to a progressive weakening in the abdominal wall, CDH occurs due to anatomical defects leading to postero-lateral wall weakness. The use of medications and environmental exposures such as allopurinol, lithium and mycophenolate mofetil as well as phenmetrazine, thalidomide, quinine, cadmium and lead can all contribute to the development of CDH. Genetic factors such as trisomy 13, trisomy 18, trisomy 21 and turner syndrome have all been associated with an increased incidence of CDH. A family history such as a parent or sibling affected may contribute to increased risk of CDH development.

Risk factors for CDH include certain drugs and genetic factors.^[1] Having a parent or sibling with the condition slightly increases your risk.

Causative drugs and Environmental exposures:^[2]

• Allopurinol
• Lithium
• Mycophenolate mofetil
• Phenmetrazine
• Thalidomide
• Quinine
• Cadmium
• Lead

Genetic Factors:

• Trisomy 13
• Trisomy 18
• Trisomy 21
• Turner syndrome