Coronavirus other diagnostic studies

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aditya Govindavarjhulla, M.B.B.S. [2]

Research laboratories have used isolation methods, electron microscopy, serology and PCR-based assays to diagnose coronavirus infections for surveillance studies.

Specific laboratory tests may include:

• Virus isolation in cell culture.
• Polymerase chain reaction (PCR) assays that are more practical and available commercially.
• Serological testing for antibodies to human coronaviruses.

Nose and throat swabs are the best specimens for detecting common human coronaviruses. Serological testing requires collection of blood specimens.

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  SEM reveals the “rosette-like” appearance of the matured coronavirus particles. From Public Health Image Library (PHIL). ^[1]
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  TEM revealed the presence of a number of infectious bronchitis virus (IBV) virions. From Public Health Image Library (PHIL). ^[1]
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  Scanning electron micrograph reveals the prolific exportation of virus particles at the pseudopodial and cell surfaces. From Public Health Image Library (PHIL). ^[1]
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  Scanning electron micrograph reveals the prolific exportation of virus particles at the pseudopodial and cell surfaces. From Public Health Image Library (PHIL). ^[1]
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  TEM from a tissue culture isolate, revealing numbers of severe acute respiratory virus (SARS) virions. From Public Health Image Library (PHIL). ^[1]

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