Creutzfeldt-Jakob disease causes

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: , Mohamadmostafa Jahansouz M.D.[2]

Overview

Creutzfeldt-Jakob disease is caused by the presence of a prion protein, an abnormal isoform of a cellular glycoprotein. Prions are transmissible particles that are devoid of nucleic acid and seem to be composed exclusively of a modified protein (PrPSc). The normal, cellular PrP (PrPC) is converted into PrPSc through a posttranslational process during which it acquires a high beta-sheet content.

Causes

Creutzfeldt-Jakob disease is caused by the presence of a prion protein, an abnormal isoform of a cellular glycoprotein.^[1]
Prions are transmissible particles that are devoid of nucleic acid and seem to be composed exclusively of a modified protein (PrPSc). The normal, cellular PrP (PrPC) is converted into PrPSc through a posttranslational process during which it acquires a high beta-sheet content.^[2]

References

↑ “http://www.cdc.gov/ncidod/dvrd/cjd/qa_cjd_infection_control.htm#what”. Retrieved 14 February 2014. External link in |title= (help)
↑ Prusiner SB (1998). “Prions”. Proc Natl Acad Sci U S A. 95 (23): 13363–83. PMC 33918. PMID 9811807.

Template:WikiDoc Sources

[www.cdc.gov-1] “http://www.cdc.gov/ncidod/dvrd/cjd/qa_cjd_infection_control.htm#what”. Retrieved 14 February 2014. External link in |title= (help)

[pmid9811807-2] Prusiner SB (1998). “Prions”. Proc Natl Acad Sci U S A. 95 (23): 13363–83. PMC 33918. PMID 9811807.

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