Cyclochlorotine
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Cyclochlorotine[1] (CC) is a secondary metabolite of the fungus Penicillium islandicum[2] that causes hepatic necrosis and has carcinogenic properties.[3] It is listed as an IARC Group 3 carcinogen.
Chemically, it is a chlorinated macrocyclic pentapeptide derived from the amino acids 3-phenyl-β-alanine, serine, dichloroproline, and aminobutyric acid.[4]
References
- ↑ Zhou, ZH; Komiyama, M; Terao, K; Shimada, Y (1994). “Effects of cyclochlorotine on myofibrils in cardiomyocytes and on actin filament bundles in fibroblasts in vitro”. Nat. Toxins. 2 (6): 378–85. PMID 7704452.
- ↑ “Toxicology of Penicillium Islandicum”. Nature. 191 (4791): 864–865. 1961. Bibcode:1961Natur.191..864.. doi:10.1038/191864b0.
- ↑ Penicillium islandicum causes hepatic necrosis and has carcinogenic properties
- ↑ Kohei Mizutani, Yusuke Hirasawa, Yoshiko Sugita-Konishi, Naoki Mochizuki and Hiroshi Morita (2008). “Structural and Conformational Analysis of Hydroxycyclochlorotine and Cyclochlorotine, Chlorinated Cyclic Peptides from Penicillium islandicum”. J. Nat. Prod. 71 (7): 1297–1300. doi:10.1021/np800150m. PMID 18558744.
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