DPPA3
Developmental pluripotency-associated protein 3 is a protein that in humans is encoded by the DPPA3 gene.[1]
This gene encodes a protein that in mice may function as a maternal factor during the preimplantation stage of development. In mice, this gene may play a role in transcriptional repression, cell division, and maintenance of cell pluripotentiality. In humans, related intronless loci are located on chromosomes 14 and X.[1]
References
Further reading
- Nakamura T, Arai Y, Umehara H, et al. (2007). “PGC7/Stella protects against DNA demethylation in early embryogenesis”. Nat. Cell Biol. 9 (1): 64–71. doi:10.1038/ncb1519. PMID 17143267.
- Elliman SJ, Wu I, Kemp DM (2006). “Adult tissue-specific expression of a Dppa3-derived retrogene represents a postnatal transcript of pluripotent cell origin”. J. Biol. Chem. 281 (1): 16–9. doi:10.1074/jbc.C500415200. PMID 16291741.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Bortvin A, Goodheart M, Liao M, Page DC (2004). “Dppa3 / Pgc7 / stella is a maternal factor and is not required for germ cell specification in mice”. BMC Dev. Biol. 4: 2. doi:10.1186/1471-213X-4-2. PMC 362866. PMID 15018652.
- Clark AT, Rodriguez RT, Bodnar MS, et al. (2004). “Human STELLAR, NANOG, and GDF3 genes are expressed in pluripotent cells and map to chromosome 12p13, a hotspot for teratocarcinoma”. Stem Cells. 22 (2): 169–79. doi:10.1634/stemcells.22-2-169. PMID 14990856.
- Bowles J, Teasdale RP, James K, Koopman P (2004). “Dppa3 is a marker of pluripotency and has a human homologue that is expressed in germ cell tumours”. Cytogenet. Genome Res. 101 (3–4): 261–5. doi:10.1159/000074346. PMID 14684992.
- Payer B, Saitou M, Barton SC, et al. (2004). “Stella is a maternal effect gene required for normal early development in mice”. Curr. Biol. 13 (23): 2110–7. doi:10.1016/j.cub.2003.11.026. PMID 14654002.
- Sato M, Kimura T, Kurokawa K, et al. (2002). “Identification of PGC7, a new gene expressed specifically in preimplantation embryos and germ cells”. Mech. Dev. 113 (1): 91–4. doi:10.1016/S0925-4773(02)00002-3. PMID 11900980.
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