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DRESS syndrome epidemiology and demographics

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Yazan Daaboul, M.D., Serge Korjian M.D.

Overview

The incidence of DRESS syndrome is approximately 10 to 100 per 100,000 drug exposures. The case-fatality rate of DRESS syndrome is approximately 10%. DRESS syndrome has been reported among patients of all ages with no gender or racial predilection.

Epidemiology and Demographics

Incidence

  • The incidence of DRESS syndrome is approximately 10 to 100 per 100,000 drug exposures.[1]

Case-Fatality Rate

  • The case-fatality rate of DRESS syndrome is approximately 10%.

Age

  • DRESS syndrome affects patients of all ages and has been reported among pediatric, adult, and elderly patients.[1]
  • In modest-sized observational studies and case series:
  • The median age for the development of DRESS syndrome is approximately 40-50 years among adult patients.[2][3]
  • The median age for the development of DRESS syndrome is approximately 10-12 years among pediatric patients.[4]

Gender

  • There is no gender predilection to the development of DRESS syndrome.

Race

  • There is no racial predilection to the development of DRESS syndrome.

References

  1. 1.0 1.1 Fiszenson-Albala F, Auzerie V, Mahe E, Farinotti R, Durand-Stocco C, Crickx B; et al. (2003). “A 6-month prospective survey of cutaneous drug reactions in a hospital setting”. Br J Dermatol. 149 (5): 1018–22. PMID 14632808.
  2. Cacoub P, Musette P, Descamps V, Meyer O, Speirs C, Finzi L; et al. (2011). “The DRESS syndrome: a literature review”. Am J Med. 124 (7): 588–97. doi:10.1016/j.amjmed.2011.01.017. PMID 21592453.
  3. Chen YC, Chiu HC, Chu CY (2010). “Drug reaction with eosinophilia and systemic symptoms: a retrospective study of 60 cases”. Arch Dermatol. 146 (12): 1373–9. doi:10.1001/archdermatol.2010.198. PMID 20713773.
  4. Carroll MC, Yueng-Yue KA, Esterly NB, Drolet BA (2001). “Drug-induced hypersensitivity syndrome in pediatric patients”. Pediatrics. 108 (2): 485–92. PMID 11483822.

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