Dendrocyte expressed seven transmembrane protein
Dendrocyte expressed seven transmembrane protein is a protein that in humans is encoded by the DCSTAMP gene.[1]
Function
This gene encodes a seven-pass transmembrane protein that is primarily expressed in dendritic cells. The encoded protein is involved in a range of immunological functions carried out by dendritic cells. This protein plays a role in osteoclastogenesis and myeloid differentiation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012].
References
Further reading
- Lee KY, Huang SM, Li S, Kim JM (February 2009). “Identification of differentially expressed genes in papillary thyroid cancers”. Yonsei Medical Journal. 50 (1): 60–7. doi:10.3349/ymj.2009.50.1.60. PMC 2649849. PMID 19259350.
- Sakai H, Okafuji I, Nishikomori R, Abe J, Izawa K, Kambe N, Yasumi T, Nakahata T, Heike T (January 2012). “The CD40-CD40L axis and IFN-γ play critical roles in Langhans giant cell formation”. International Immunology. 24 (1): 5–15. doi:10.1093/intimm/dxr088. PMID 22058328.
- Eleveld-Trancikova D, Triantis V, Moulin V, Looman MW, Wijers M, Fransen JA, Lemckert AA, Havenga MJ, Figdor CG, Janssen RA, Adema GJ (March 2005). “The dendritic cell-derived protein DC-STAMP is highly conserved and localizes to the endoplasmic reticulum”. Journal of Leukocyte Biology. 77 (3): 337–43. doi:10.1189/jlb.0804441. PMID 15601667.
- Beauregard M, Gagnon E, Guay-Bélanger S, Morissette J, Brown JP, Michou L (June 2014). “Identification of rare genetic variants in novel loci associated with Paget’s disease of bone”. Human Genetics. 133 (6): 755–68. doi:10.1007/s00439-013-1409-x. PMID 24370779.
- Kim HY, Cho S, Yu J, Sung S, Kim H (August 2010). “Analysis of copy number variation in 8,842 Korean individuals reveals 39 genes associated with hepatic biomarkers AST and ALT”. BMB Reports. 43 (8): 547–53. PMID 20797317.
- Eleveld-Trancikova D, Sanecka A, van Hout-Kuijer MA, Looman MW, Hendriks IA, Jansen BJ, Adema GJ (July 2010). “DC-STAMP interacts with ER-resident transcription factor LUMAN which becomes activated during DC maturation”. Molecular Immunology. 47 (11–12): 1963–73. doi:10.1016/j.molimm.2010.04.019. PMID 20546900.
- Zeng Z, Zhang C, Chen J (July 2013). “Lentivirus-mediated RNA interference of DC-STAMP expression inhibits the fusion and resorptive activity of human osteoclasts”. Journal of Bone and Mineral Metabolism. 31 (4): 409–16. doi:10.1007/s00774-013-0434-0. PMID 23525827.
- Hartgers FC, Looman MW, van der Woning B, Merkx GF, Figdor CG, Adema GJ (March 2001). “Genomic organization, chromosomal localization, and 5′ upstream region of the human DC-STAMP gene”. Immunogenetics. 53 (2): 145–9. doi:10.1007/s002510100302. PMID 11345591.
- Chiu YH, Mensah KA, Schwarz EM, Ju Y, Takahata M, Feng C, McMahon LA, Hicks DG, Panepento B, Keng PC, Ritchlin CT (January 2012). “Regulation of human osteoclast development by dendritic cell-specific transmembrane protein (DC-STAMP)”. Journal of Bone and Mineral Research. 27 (1): 79–92. doi:10.1002/jbmr.531. PMC 3304467. PMID 21987375.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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