Dermatofibroma classification

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Homa Najafi, M.D.[2]

Overview

Dermatofibroma may be classified according to histopathology into three groups, variants that are prominent in architectural (low-power) properties, variants that are prominent in cytologic or stromal (high-power) properties, and variants that have architectural (low) and cytological or stromal (high-power) properties.

Classification

Dermatofibroma may be classified according to histopathology into three groups:^[1]^[2]^[3]^[4]^[5]^[6]^[7]^[8]^[9]

Variants that are prominent in architectural (low-power) properties
Variants that are prominent in cytologic or stromal (high-power) properties
Variants that have architectural (low) and cytological or stromal (high-power) properties

Histopathology varient of dermatofibroma

Variants that are prominent in architectural (low-power) properties

Variants that are prominent in cytologic or stromal (high-power) properties

Variants that have architectural (low) and cytological or stromal (high-power) properties

1. Deep penetrating dermatofibroma

2. Atrophic dermatofibroma

3. Aneurysmal fibrous histiocytoma

4. Haemangiopericytoma-like fibrous histiocytoma

5. Palisading cutaneous fibrous histiocytoma

6. Lichenoid, erosive, & ulcerated dermatofibroma

7. Plaque-like dermal fibromatosis, dermatofibroma

1. Clear cell dermatofibroma

2. Granular cell dermatofibroma

3. Myofibroblastic dermatofibroma

4. Sclerotic dermatofibroma

5. Keloidal dermatofibroma

6. Atypical/pseudosarcomatous fibrous histiocytoma, dermatofibroma with monster cells

7. Hemosiderrhotic dermatofibroma

8. Cholesterotic/lipidized dermatofibroma

9. Myxoid dermatofibroma

10. Ossifying dermatofibroma

11. Pseudolymphomatous dermatofibroma

12. Dermatofibroma with diffuse eosinophilic infiltrate

1. Epithelioid cell histiocytoma

2. Cellular benign fibrous histiocytoma

3. Smooth muscle proliferation in dermatofibroma

4. Multinucleate cell angiohistiocytoma

5. Cellular neurothekeoma

6. Combined dermatofibroma

References

↑ B. G. Zelger, A. Sidoroff & B. Zelger (2000). “Combined dermatofibroma: co-existence of two or more variant patterns in a single lesion”. Histopathology. 36 (6): 529–539. PMID 10849095.
↑ Jones, E. Wilson; Cerio, R.; Smith, N.P. (2006). “Epithelioid cell histiocytoma: a new entity”. British Journal of Dermatology. 120 (2): 185–195. doi:10.1111/j.1365-2133.1989.tb07782.x. ISSN 0007-0963.
↑ Zelger, B W; Zelger, B G; Steiner, H; Ofner, D (1996). “Aneurysmal and haemangiopericytoma-like fibrous histiocytoma”. Journal of Clinical Pathology. 49 (4): 313–318. doi:10.1136/jcp.49.4.313. ISSN 0021-9746.
↑ J. S. Silverman & S. Brustein (1996). “Myxoid dermatofibrohistiocytoma: an indolent post-traumatic tumor composed of CD34+ epithelioid and dendritic cells and factor XIIIa+ dendrophages”. Journal of cutaneous pathology. 23 (6): 551–557. PMID 9001986.
↑ B. G. Zelger, E. Calonje & B. Zelger (1999). “Myxoid dermatofibroma”. Histopathology. 34 (4): 357–364. PMID 10231403.
↑ E. J. Glusac & J. M. McNiff (1999). “Epithelioid cell histiocytoma: a simulant of vascular and melanocytic neoplasms”. The American Journal of dermatopathology. 21 (1): 1–7. PMID 10027517.
↑ E. Calonje, T. Mentzel & C. D. Fletcher (1994). “Cellular benign fibrous histiocytoma. Clinicopathologic analysis of 74 cases of a distinctive variant of cutaneous fibrous histiocytoma with frequent recurrence”. The American journal of surgical pathology. 18 (7): 668–676. PMID 8017561.
↑ B. W. Zelger, H. Steiner & H. Kutzner (1996). “Clear cell dermatofibroma. Case report of an unusual fibrohistiocytic lesion”. The American journal of surgical pathology. 20 (4): 483–491. PMID 8604817.
↑ J. F. Val-Bernal & C. Mira (1996). “Dermatofibroma with granular cells”. Journal of cutaneous pathology. 23 (6): 562–565. PMID 9001988.

[1] B. G. Zelger, A. Sidoroff & B. Zelger (2000). “Combined dermatofibroma: co-existence of two or more variant patterns in a single lesion”. Histopathology. 36 (6): 529–539. PMID 10849095.

[JonesCerio2006-2] Jones, E. Wilson; Cerio, R.; Smith, N.P. (2006). “Epithelioid cell histiocytoma: a new entity”. British Journal of Dermatology. 120 (2): 185–195. doi:10.1111/j.1365-2133.1989.tb07782.x. ISSN 0007-0963.

[ZelgerZelger1996-3] Zelger, B W; Zelger, B G; Steiner, H; Ofner, D (1996). “Aneurysmal and haemangiopericytoma-like fibrous histiocytoma”. Journal of Clinical Pathology. 49 (4): 313–318. doi:10.1136/jcp.49.4.313. ISSN 0021-9746.

[4] J. S. Silverman & S. Brustein (1996). “Myxoid dermatofibrohistiocytoma: an indolent post-traumatic tumor composed of CD34+ epithelioid and dendritic cells and factor XIIIa+ dendrophages”. Journal of cutaneous pathology. 23 (6): 551–557. PMID 9001986.

[5] B. G. Zelger, E. Calonje & B. Zelger (1999). “Myxoid dermatofibroma”. Histopathology. 34 (4): 357–364. PMID 10231403.

[6] E. J. Glusac & J. M. McNiff (1999). “Epithelioid cell histiocytoma: a simulant of vascular and melanocytic neoplasms”. The American Journal of dermatopathology. 21 (1): 1–7. PMID 10027517.

[7] E. Calonje, T. Mentzel & C. D. Fletcher (1994). “Cellular benign fibrous histiocytoma. Clinicopathologic analysis of 74 cases of a distinctive variant of cutaneous fibrous histiocytoma with frequent recurrence”. The American journal of surgical pathology. 18 (7): 668–676. PMID 8017561.

[8] B. W. Zelger, H. Steiner & H. Kutzner (1996). “Clear cell dermatofibroma. Case report of an unusual fibrohistiocytic lesion”. The American journal of surgical pathology. 20 (4): 483–491. PMID 8604817.

[9] J. F. Val-Bernal & C. Mira (1996). “Dermatofibroma with granular cells”. Journal of cutaneous pathology. 23 (6): 562–565. PMID 9001988.

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