Dienestrol

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Dienestrol is a synthetic estrogen.

1. Pinacol coupling of p–acetoxy–propiophenone.
2. Dehydration of the thus-obtained glycol with a mixture of acetyl chloride and acetic anhydride leads to the transoid diene system (bis–β-Methylstyrene-type).
3. Saponification removes the acetate groups and thus affords dienestrol.

• Diethylstilbestrol