Diffuse large B cell lymphoma history and symptoms

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2] Anila Hussain, MD [3]

The most common symptoms of diffuse large B cell lymphoma include a rapidly enlarging, non-painful mass that may be located in neck, groin, or abdomen. The less common symptoms of diffuse large B cell lymphoma include fever, weight loss, and drenching night sweats also known as ”B symptoms”^[1][2].

• Mass/Lump

• Rapidly enlarging lump (enlarged lymph nodes)
• Painless
• May be present in neck, groin or abdomen
• It is not uncommon to have lymphoma outside the Lymph nodes(Extranodal sites) and can lead to the rapid Progression to Large lumps.

• Localized symptoms:

Other symptoms might depend on the organ of Involvement for example DLBCL in Chest can lead to shortness of breath or cough while DLBCL involving gut or Stomach can cause Abdominal Pain/ Diarrhea/ Bleeding etc.

• Fever
• Unexplained Weight loss( more than 10 percent over a period of 6 Months)
• Night sweats

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