Dobrava-Belgrade virus

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

OVERVIEW

Dobrava-Belgrade virus (DOBV), also known as Dobrava virus, is an enveloped, single-stranded, negative-sense RNA virus species of Old World Hantavirus. It is one of several species of Hantavirus that is the causative agent of severe Hantavirus hemorrhagic fever with renal syndrome. It was first isolated from yellow-necked mice (Apodemus flavicollis) found in Dobrava Village, Slovenia, Yugoslavia.^[1] It was subsequently isolated in striped field mice in Estonia and other parts of Eastern Europe. It has also been found in Germany but the reservoir host there is unknown.^[2]

Reservoir

Dobrava virus and the variants of Dobrava-Belgrade virus have been found in the Yellow-necked mouse (Apodemus flavicollis), the Striped field mouse (Apodemus agrarius) and Black Sea field mouse (Apodemus ponticus).

Morbidity and Mortality

The fatality rate is 12%, making Dobrava virus the most life-threatening hantavirus disease in Europe. Variant DOBV genotypes have different degrees of pathogenicity.^[3]

References

↑ Avsic-Zupanc T, Xiao SY, Stojanovic R, Gligic A, van der Groen G, LeDuc JW (Oct 1992). “Characterization of Dobrava virus: a Hantavirus from Slovenia, Yugoslavia”. J Med Virol. 38 (2): 132–7.
↑ Schlegel1 Mathias, Klempa Boris, Auste Brita, Bemmann Margrit, Schmidt-Chanasit Jonas, Büchner Thomas, Groschup Martin H., Meier Markus, Balkema-Buschmann Anne, Zoller Hinrich, Krüger Detlev H., Ulrich Rainer G. (2009). “Dobrava-Belgrade Virus Spillover Infections, Germany”. Dispatch. 15 (12).
↑ Papa A (Aug 2012). “Dobrava-Belgrade virus: phylogeny, epidemiology, disease”. Antiviral Res. 95 (2): 104–17. doi:10.1016/j.antiviral.2012.05.011.

External links

Sloan Science and Film / Short Films / Muerto Canyon by Jen Peel 29 minutes
“Hantaviruses, with emphasis on Four Corners Hantavirus” by Brian Hjelle, M.D., Department of Pathology, School of Medicine, University of New Mexico
CDC’s Hantavirus Technical Information Index page
Viralzone: Hantavirus
Virus Pathogen Database and Analysis Resource (ViPR): Bunyaviridae
Occurrences and deaths in North and South America

[1] Avsic-Zupanc T, Xiao SY, Stojanovic R, Gligic A, van der Groen G, LeDuc JW (Oct 1992). “Characterization of Dobrava virus: a Hantavirus from Slovenia, Yugoslavia”. J Med Virol. 38 (2): 132–7.

[2] Schlegel1 Mathias, Klempa Boris, Auste Brita, Bemmann Margrit, Schmidt-Chanasit Jonas, Büchner Thomas, Groschup Martin H., Meier Markus, Balkema-Buschmann Anne, Zoller Hinrich, Krüger Detlev H., Ulrich Rainer G. (2009). “Dobrava-Belgrade Virus Spillover Infections, Germany”. Dispatch. 15 (12).

[3] Papa A (Aug 2012). “Dobrava-Belgrade virus: phylogeny, epidemiology, disease”. Antiviral Res. 95 (2): 104–17. doi:10.1016/j.antiviral.2012.05.011.

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