Dyspepsia future or investigational therapies

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Future or Investigational Therapies

A 2004 meta-analysis pooling data from three double-blind placebo-controlled studies found the multiple herbal extract Iberogast to be significantly more effective than placebo (p value = 0.001) at treating patients with functional dyspepsia through the targeting of multiple dyspeptic pathologies.^[1] This German-made phytopharmaceutical was found to be equivalent to cisapride and significantly superior to metochlopramide at reducing the symptoms of functional dyspepsia over a four week period.^[2]^[3] Retrospective surveillance of 40,961 children (12 years and under) found no serious side-effects.^[4]

References

↑ Melzer J, Rosch W, Reichling J, Brignoli R, Saller R (2004). “Meta-analysis: phytotherapy of functional dyspepsia with the herbal drug preparation STW-5 (Iberogast)”. Aliment Pharmacol Ther. 20: 1279&ndash, 87.
↑ Rosch w, Vinson B, Sassin, I (2002). “A randomised clinical trial comparing the efficacy of a herbal preparation STW 5 with the prokinetic drug cisapride in patients with dysmotility type of functional dyspepsia”. Z Gastroenterol. 40: 401&ndash, 8.
↑ Hanisch J, Bock P, Vinson B (2005). “The efficacy and safety of STW 5 versus Metochlopramide oral for functional dyspepsia under practice conditions (in German)”. Med Klinik. 100. Text “pages107” ignored (help)
↑ Liechtle K (1999). “Experience reports on the use of Iberogast in children (in German)”. Forschungsbericht Steigerwald Arzneimittelwerk. GmbH.

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[Melzer2004-1] Melzer J, Rosch W, Reichling J, Brignoli R, Saller R (2004). “Meta-analysis: phytotherapy of functional dyspepsia with the herbal drug preparation STW-5 (Iberogast)”. Aliment Pharmacol Ther. 20: 1279&ndash, 87.

[Rosch2002-2] Rosch w, Vinson B, Sassin, I (2002). “A randomised clinical trial comparing the efficacy of a herbal preparation STW 5 with the prokinetic drug cisapride in patients with dysmotility type of functional dyspepsia”. Z Gastroenterol. 40: 401&ndash, 8.

[Hanisch2005-3] Hanisch J, Bock P, Vinson B (2005). “The efficacy and safety of STW 5 versus Metochlopramide oral for functional dyspepsia under practice conditions (in German)”. Med Klinik. 100. Text “pages107” ignored (help)

[Leichtle1999-4] Liechtle K (1999). “Experience reports on the use of Iberogast in children (in German)”. Forschungsbericht Steigerwald Arzneimittelwerk. GmbH.

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