Dyspepsia natural history, complications and prognosis

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Ajay Gade MD [2]]

Overview

Dyspepsia usually persists throughout life and the chance of spontaneous healing is rare. Dyspepsia is most commonly associated with Helicobacter pylori infection. Increase in the prevalence of dyspepsia is attributed to the increasing age and the onset varies among different ethnicities. An increased risk of developing peptic ulcers has been observed in individuals with persistent dyspepsia. Dyspepsia is associated with complications such as peptic ulcers, anemia due to gastritis, stomach cancer, vitamin B12 deficiency, pernicious anemia. Functional dyspepsia is a long-lasting disorder with an excellent prognosis regardless of H. pylori infection.

Natural History

Dyspepsia usually persists throughout life and the chance of spontaneous healing is rare.
Dyspepsia is most commonly associated with Helicobacter pylori infection.
Increase in the prevalence of dyspepsia is attributed to the increasing age and the onset varies among different ethnicities.
An increased risk of developing peptic ulcers has been observed in individuals with persistent dyspepsia.^[1]^[2]^[3]

Complications

Peptic ulcers
Anemia due to gastritis
Stomach cancer
Vitamin B12 deficiency
Pernicious anemia
Increased risk of developing benign or malignant growths in the lining of the stomach.

Prognosis

Functional dyspepsia is a long-lasting disorder with an excellent prognosis regardless of H. pylori infection.

References

↑ Redéen S, Petersson F, Kechagias S, Mårdh E, Borch K (2010). “Natural history of chronic gastritis in a population-based cohort”. Scand J Gastroenterol. 45 (5): 540–9. doi:10.3109/00365521003624151. PMID 20180646.
↑ Sipponen P, Kekki M, Siurala M (1991). “The Sydney System: epidemiology and natural history of chronic gastritis”. J Gastroenterol Hepatol. 6 (3): 244–51. PMID 1912435.
↑ Sipponen P (1992). “Natural history of gastritis and its relationship to peptic ulcer disease”. Digestion. 51 Suppl 1: 70–5. PMID 1397747.

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[pmid20180646-1] Redéen S, Petersson F, Kechagias S, Mårdh E, Borch K (2010). “Natural history of chronic gastritis in a population-based cohort”. Scand J Gastroenterol. 45 (5): 540–9. doi:10.3109/00365521003624151. PMID 20180646.

[pmid1912435-2] Sipponen P, Kekki M, Siurala M (1991). “The Sydney System: epidemiology and natural history of chronic gastritis”. J Gastroenterol Hepatol. 6 (3): 244–51. PMID 1912435.

[pmid1397747-3] Sipponen P (1992). “Natural history of gastritis and its relationship to peptic ulcer disease”. Digestion. 51 Suppl 1: 70–5. PMID 1397747.

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