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Dysphagia resident survival guide

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mounika Reddy Vadiyala, M.B.B.S.[2]

Synonyms and keywords: Approach to dysphagia, Dysphagia algorithm, Dysphagia workup, Dysphagia management, Dysphagia diagnostic approach

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Overview

Dysphagia is defined as “difficulty swallowing.” It is a sensation that suggests difficulty in the passage of solids or liquids from the mouth to the stomach. According to the International Classification of Diseases (ICD-10) which is endorsed by the WHO, dysphagia is a symptom rather than a disease. Dysphagia can result from propulsive failure, motility disorders, structural disorders, intrinsic or extrinsic compression of the oropharynx or esophagus. Dysphagia is distinguished from similar symptoms including odynophagia, which is defined as painful swallowing, and globus, which is the sensation of a lump in the throat. The endoscopy for esophageal dysphagia should be performed when the patient presented with symptoms of difficulty swallowing, painful swallowing, and aspiration. This is the standard test performed when the patient has a risk of developing pneumonia and diagnosing swallowing difficulties. Videofluoroscopic swallowing study is performed for oropharyngeal dysphagia. It provides information about delay in initiation of pharyngeal swallowing, nasopharyngeal regurgitation, residue of ingested food within the pharyngeal cavity after swallowing, and aspiration of ingested food. The cornerstone of any dysphagia evaluation is a detailed history and a thorough review of symptoms that can differentiate esophageal from oropharyngeal dysphagia and help predict the specific etiology of dysphagia with an accuracy of approximately 80% confirmed by specific testing. How a patient describes his or her difficulty and its timing, associated symptoms, and other characterizations may specifically denote the anatomic level of swallowing dysfunction.

Causes

Life Threatening Causes

Life-threatening causes include conditions that may result in death or permanent disability within 24 hours if left untreated. There are no known life-threatening causes of dysphagia.

Common Causes

Depending upon the type of dysphagia, the causes can be categorized into two subsections:[1][2][3][4][5][6]

Common Causes of Oropharyngeal Dysphagia

Common causes of oropharyngeal dysphagia
Neuromuscular disorders Mechanical and obstructive causes Medication side effects Others
Medications that reduce salivary flow:

    Common Causes of Esophageal Dysphagia

    The common causes of esophageal dysphagia can be divided into four categories.[7][8][9][10][11]

    Structural (Mechanical) disorders Motor disorders Esophageal tumors Systemic diseases Miscellaneous
    Intrinsic compression Extrinsic Compression Primary Secondary
    Mucosal rings and webs Strictures: Vascular compression:

    Less Common Causes

    Less common causes of dysphagia include:

    To review a complete list of dysphagia causes, click here

    Diagnosis


     
     
     
     
     
     
     
    Patient with Dysphagia
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
    Difficulty in initiating a swallow
    associated with cough, choking
    or nasal regurgitation
     
     
     
     
     
    Dysphagia to solids and liquids, or solids,
    sensation of food stuck in esophagus
    (seconds after initiating swallow)
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
    Oropharyngeal dysphagia
     
     
     
     
     
    Esophageal dysphagia
     


    Shown below is an algorithm summarizing the diagnosis of Oropharyngeal dysphagia according to the the World Gastroenterology Organisation Global Guidelines, International consensus (ICON) on assessment of oropharyngeal dysphagia and AGA technical review on management of oropharyngeal dysphagia.[1][4][2]

     
     
     
     
     
     
     
     
    Dysphagia
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
    History and Physical examination
     
     
    Identify alternate diagnoses such as xerostomia, globus, esophageal dysphagia
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
    Laboratory findings and CNS imaging
     
     
    Identify syndromes with specific treatment such as myasthenia gravis, toxic and metabolic myopathies, CNS tumors
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
    No systemic disease identified
     
     
     
    Neuromuscular disorders without specific treatment
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
    Nasoendoscopy (to evaluate for structural causes of dysphagia)
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
    Videofluoroscopic swallowing +/-manometry (to characterise severity and mechanism of swallow dysfunction)
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
    Structural lesions with specific therapy such as zenker’s diverticulum, orophayngeal tumors
     
    Severe dysfunction or risk of aspiration pneumonia necessitating the institution of nonoral feeding, tracheostomy
     
     
    Dysphagia ammendable to cricophayngeal myotomy
     
    Dysphagia ammendable to specific therapy (diet modification, swallow therapy +/- temporary nonoral feeding)
     


    Shown below is an algorithm summarizing the diagnosis of Esophageal dysphagia according the the World Gastroenterology Organisation Global Guidelines, and Clinical Practice Guidelines for the Assessment of Uninvestigated Esophageal Dysphagia.[1][6]

     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
    Dysphagia to solids and liquids
     
     
     
     
     
     
     
     
     
     
    Dysphagia to solids (may progress to liquids)
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
    Motility disorders
     
     
     
     
     
     
     
     
     
     
    Mechanical obstruction
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
    Intermittent
     
     
     
     
     
    Progressive
     
     
     
    Acute
     
    Intermittent
     
    Progressive
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
    Chronic heartburn
     
    Regurgitation and/or respiratory symptoms
     
     
     
     
     
     
     
     
     
    Chronic heartburn
     
    Elderly (>50 years), weight loss, anemia
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
    Primary motility disorders
     
    Secondary motility disorders
     
    Scleroderma
     
    Achalasia
     
    Foreign body
     
     
     
    Esophageal or cardia carcinomas
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
    Manometry
     
     
     
     
     
     
     
     
     
     
     
     
     
     
    Endoscopy (+/-esophageal biopsy)
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
    Barium Swallow indicated when:
    Endoscopy findings are normal
    ❑ Endoscopy is contraindicated due to:
    ❑ History of surgery for esophageal/laryngeal cancer
    ❑ History of radiation
    Caustic injury
    ❑ Complex stricture
    ❑ Risk of perforation
    Endoscopy access is limited
     
     
     
     

    Treatment

    Shown below is an algorithm summarizing the treatment of Oropharyngeal dysphagia according to the the World Gastroenterology Organisation Global Guidelines, International consensus (ICON) on assessment of oropharyngeal dysphagia and AGA technical review on management of oropharyngeal dysphagia.[1][4][2]

     
     
     
     
     
     
     
     
     
     
    Systemic disease with specific therapy
    such as myasthenia gravis, myopathies,
    parkinson’s disease, infections and others
     
    Treat the underlying disease
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
    CNS tumors and oropharyngeal tumors
     
    Surgical resection, chemotherapy or radiotherapy
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
    Oropharyngeal dysphagia
     
     
     
     
     
    Structural disorders such as cervical webs
    and rings, zenker’s diverticulum and others
     
    Treatment of the disorder
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
    Medication side effects
     
    Discontinue medication
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
    Severe dysfunction and
    risk of aspiration pneumonia
     
    ❑ Non-oral feeding
    Tracheostomy
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
    Neuromuscular disorder without specific therapy such as stroke, dengerative diseases and others
     
     
     
    Cricopharynegal dysfunction
     
    Cricopharyngeal myotomy
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
    Rehabilitation
     
    Swallowing maneuvers and postural techniques
    ❑ Dietary modification
    ❑ Temporary non-oral feeding
     
     
     
     


    Shown below is an algorithm summarizing the management of Esophageal dysphagia according the the World Gastroenterology Organisation Global Guidelines, and Clinical Practice Guidelines for the Assessment of Uninvestigated Esophageal Dysphagia.[1][6]

     
     
    Esophageal dysphagia
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
    Age>50 years, weight loss,
    anemia and other alarm
    signs and symptoms
     
     
    Endoscopy +/- other imaging studies
     
     
    Surgical resection or
    chemotherapyof the detected
    esophageal carcinoma
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
    No
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
    GERD symptoms
     
     
    Proton pump inhibitor trial for 4 weeks
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
    No
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
    Dysphagia unresolved
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
    Structural or inflammatory
    lesions detected on endoscopy
    and/or barium swallow
     
     
    Treat the detected lesions
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
    No
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
    Esophageal manometry
     
     
    Treat the
    detected motility disorders
     
     
     
     
     
     
     

    Do’s

    • Evaluate for drugs causing decreased salivary flow or those causing esophageal mucosal injury.
    • Treat underlying disorders first.

    Don’ts

    References

    1. 1.0 1.1 1.2 1.3 1.4 Malagelada, Juan-R.; Bazzoli, Franco; Boeckxstaens, Guy; De Looze, Danny; Fried, Michael; Kahrilas, Peter; Lindberg, Greger; Malfertheiner, Peter; Salis, Graciela; Sharma, Prateek; Sifrim, Daniel; Vakil, Nimish; Le Mair, Anton (2015). “World Gastroenterology Organisation Global Guidelines”. Journal of Clinical Gastroenterology. 49 (5): 370–378. doi:10.1097/MCG.0000000000000307. ISSN 0192-0790.
    2. 2.0 2.1 2.2 Cook, Ian J.; Kahrilas, Peter J. (1999). “AGA technical review on management of oropharyngeal dysphagia”. Gastroenterology. 116 (2): 455–478. doi:10.1016/S0016-5085(99)70144-7. ISSN 0016-5085.
    3. Philpott, Hamish; Garg, Mayur; Tomic, Dunya; Balasubramanian, Smrithya; Sweis, Rami (2017). “Dysphagia: Thinking outside the box”. World Journal of Gastroenterology. 23 (38): 6942–6951. doi:10.3748/wjg.v23.i38.6942. ISSN 1007-9327.
    4. 4.0 4.1 4.2 Espitalier, F.; Fanous, A.; Aviv, J.; Bassiouny, S.; Desuter, G.; Nerurkar, N.; Postma, G.; Crevier-Buchman, L. (2018). “International consensus (ICON) on assessment of oropharyngeal dysphagia”. European Annals of Otorhinolaryngology, Head and Neck Diseases. 135 (1): S17–S21. doi:10.1016/j.anorl.2017.12.009. ISSN 1879-7296.
    5. Abdel Jalil, Ala’ A.; Katzka, David A.; Castell, Donald O. (2015). “Approach to the Patient with Dysphagia”. The American Journal of Medicine. 128 (10): 1138.e17–1138.e23. doi:10.1016/j.amjmed.2015.04.026. ISSN 0002-9343.
    6. 6.0 6.1 6.2 Liu, Louis W C; Andrews, Christopher N; Armstrong, David; Diamant, Nicholas; Jaffer, Nasir; Lazarescu, Adriana; Li, Marilyn; Martino, Rosemary; Paterson, William; Leontiadis, Grigorios I; Tse, Frances (2018). “Clinical Practice Guidelines for the Assessment of Uninvestigated Esophageal Dysphagia”. Journal of the Canadian Association of Gastroenterology. 1 (1): 5–19. doi:10.1093/jcag/gwx008. ISSN 2515-2084.
    7. Xiao Y, Kahrilas PJ, Nicodème F, Lin Z, Roman S, Pandolfino JE (2014). “Lack of correlation between HRM metrics and symptoms during the manometric protocol”. Am J Gastroenterol. 109 (4): 521–6. doi:10.1038/ajg.2014.13. PMC 4120962. PMID 24513804.
    8. Enestvedt BK, Williams JL, Sonnenberg A (2011). “Epidemiology and practice patterns of achalasia in a large multi-centre database”. Aliment Pharmacol Ther. 33 (11): 1209–14. doi:10.1111/j.1365-2036.2011.04655.x. PMC 3857989. PMID 21480936.
    9. Howard PJ, Maher L, Pryde A, Cameron EW, Heading RC (1992). “Five year prospective study of the incidence, clinical features, and diagnosis of achalasia in Edinburgh”. Gut. 33 (8): 1011–5. PMC 1379432. PMID 1398223.
    10. Pandolfino JE, Gawron AJ (2015). “Achalasia: a systematic review”. JAMA. 313 (18): 1841–52. doi:10.1001/jama.2015.2996. PMID 25965233.
    11. Gockel I, Lord RV, Bremner CG, Crookes PF, Hamrah P, DeMeester TR (2003). “The hypertensive lower esophageal sphincter: a motility disorder with manometric features of outflow obstruction”. J Gastrointest Surg. 7 (5): 692–700. PMID 12850684.
    12. Chatterjee S, Hedman BJ, Kirby DF (2017). “An Unusual Cause of Dysphagia”. J Clin Rheumatol. doi:10.1097/RHU.0000000000000666. PMID 29280826.
    13. Wright RA, Bernie H (1982). “Scleredema adultorum of Buschke with upper esophageal involvement”. Am J Gastroenterol. 77 (1): 9–11. PMID 7064968.
    14. Nguyen NP, Sallah S, Karlsson U, Antoine JE (2002). “Combined chemotherapy and radiation therapy for head and neck malignancies: quality of life issues”. Cancer. 94 (4): 1131–41. PMID 11920484.
    15. Conte, Blagio A. (1966). “Dysphagia Caused by an Aneurysm of the Descending Thoracic Aorta”. New England Journal of Medicine. 274 (17): 956–957. doi:10.1056/NEJM196604282741710. ISSN 0028-4793.
    16. Benedict, Edward B.; Sweet, Richard H. (1955). “Dysphagia Due to Hypertrophy of the Cricopharyngeus Muscle or Hypopharyngeal Bar”. New England Journal of Medicine. 253 (26): 1161–1162. doi:10.1056/NEJM195512292532607. ISSN 0028-4793.

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